Purisima Creek is an 8.0-mile-long (12.9 km) stream in San Mateo County, California which rises 1.3 miles (2.1 km) north of Sierra Morena, a mountain in the Santa Cruz Mountains, and flows westward to the Pacific Ocean 2.3 miles (3.7 km) south-southeast of Miramontes Point. Much of its watershed has been incorporated in the Purisima Creek Redwoods Open Space Preserve.