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- Prostaglandin H2 (PGH2) ist ein Zwischenprodukt der Prostaglandin-Synthese in Wirbeltieren. Es wird durch die Cyclooxygenasen in zwei Schritten aus Arachidonsäure biosynthetisch gebildet. PGH2 stimuliert Entzündungsreaktionen und regelt die Sekretion von Magensaft. Die Acetylsalicylsäure erzielt ihre Wirkung, indem sie die Cyclooxygenasen hemmt. Dabei acetyliert Acetylsalicylsäure das Ser530 der Prostaglandin-H-Synthase und versperrt somit den Kanal, so dass die Arachidonsäure von der Membran nicht mehr ins aktive Zentrum des Enzyms kommen kann. Prostaglandin H2 ist Ausgangssubstanz für weitere Hormone: Prostaglandin I2, Prostaglandin E2, Prostaglandin D2 und Prostaglandin F2 sowie Thromboxan A2. (de)
- La prostaglandine H2 (PGH2) est un précurseur des prostaglandines chez les vertébrés, dérivé de l'acide arachidonique en deux étapes par des cyclooxygénases. Elle augmente l'inflammation et régule la sécrétion du suc gastrique. L'action anti-inflammatoire de l'acide acétylsalicylique (aspirine) est due à l'inhibition de la cyclooxygénase-1. La PGH2 est notamment le substrat des enzymes suivantes, qui conduisent à divers composés biochimiques physiologiquement importants :
* la pour former de la prostacycline ;
* la pour former du thromboxane A2 ;
* la pour former de la prostaglandine D2 ;
* la pour former de la prostaglandine E2. (fr)
- Prostaglandin H2 is a type of prostaglandin and a precursor for many other biologically significant molecules. It is synthesized from arachidonic acid in a reaction catalyzed by a cyclooxygenase enzyme. The conversion from Arachidonic acid to Prostaglandin H2 is a two step process. First, COX-1 catalyzes the addition of two free oxygens to form the 1,2-Dioxane bridge and a peroxide functional group to form Prostaglandin G2. Second, COX-2 reduces the peroxide functional group to a Secondary alcohol, forming Prostaglandin H2. Other peroxidases like Hydroquinone have been observed to reduce PGG2 to PGH2. PGH2 is unstable at room temperature, with a half life of 90-100 seconds, so it is often converted into a different prostaglandin. It is acted upon by:
* Prostacyclin synthase to create prostacyclin
* Thromboxane-A synthase to create thromboxane A2 and 12-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid (HHT) (see 12-Hydroxyheptadecatrienoic acid)
* Prostaglandin D2 synthase to create prostaglandin D2
* Prostaglandin E synthase to create prostaglandin E2 It rearranges non-enzymatically to:
* A mixture of 12-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid (HHT) and 12-(S)-hydroxy-5Z,8Z,10E-heptadecatrienoic acid (see 12-Hydroxyheptadecatrienoic acid) Use of prostaglandin H2:
* regulating the constriction and dilation of blood vessels
* stimulating platelet aggregation
* binds to Thromboxane receptor on platelets' cell membranes to trigger platelet migration and adhesion to other platelets. Effects of Aspirin on prostaglandin H2:
* Aspirin has been hypothesized to block the conversion of arachidonic acid to prostaglandin (en)
- La prostaglandina H2 è un tipo di prostaglandina derivata direttamente dall'acido arachidonico. Dalla PGH2 derivano molte altre prostaglandine ed il trombossano A2. (it)
- A Prostaglandina H2 (PGH2) é um mediador lipídico derivado do ácido araquidónico, da família das Prostaglandinas, um sub-grupo dos Eicosanóides. É sintetizada a partir da PGG2 pela enzima ciclo-oxigenase (COX), também denominada de prostaglandina H sintetase. É um dos compostos da via metabólica da cascata do ácido araquidónico e, como tal, é um importante mediador de vários processos fisiológicos e patológicos. No contexto da cascata do ácido araquidónico é precursora de uma série de moléculas biologicamente relevantes:
* Prostaglandina I2 (PGI2)ou prostaciclina, através da ;
* Prostaglandina D2 (PGD2), através da
* Prostaglandina E2 (PGE2), através da
* (TXA2), através da (pt)
- 前列腺素H2是由花生四烯酸衍生而来的一種前列腺素，它可以進步一步衍生成其他的前列腺素和血栓素。 (zh)
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- PGH2, Endoperoxide H2, Prostaglandin R2 (en)
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- 5689 (xsd:nonNegativeInteger)
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- Prostaglandin H2 skeletal.svg (en)
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- PGH2, Endoperoxide H2, Prostaglandin R2 (en)
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- La prostaglandina H2 è un tipo di prostaglandina derivata direttamente dall'acido arachidonico. Dalla PGH2 derivano molte altre prostaglandine ed il trombossano A2. (it)
- 前列腺素H2是由花生四烯酸衍生而来的一種前列腺素，它可以進步一步衍生成其他的前列腺素和血栓素。 (zh)
- Prostaglandin H2 (PGH2) ist ein Zwischenprodukt der Prostaglandin-Synthese in Wirbeltieren. Es wird durch die Cyclooxygenasen in zwei Schritten aus Arachidonsäure biosynthetisch gebildet. PGH2 stimuliert Entzündungsreaktionen und regelt die Sekretion von Magensaft. Die Acetylsalicylsäure erzielt ihre Wirkung, indem sie die Cyclooxygenasen hemmt. Dabei acetyliert Acetylsalicylsäure das Ser530 der Prostaglandin-H-Synthase und versperrt somit den Kanal, so dass die Arachidonsäure von der Membran nicht mehr ins aktive Zentrum des Enzyms kommen kann. (de)
- Prostaglandin H2 is a type of prostaglandin and a precursor for many other biologically significant molecules. It is synthesized from arachidonic acid in a reaction catalyzed by a cyclooxygenase enzyme. The conversion from Arachidonic acid to Prostaglandin H2 is a two step process. First, COX-1 catalyzes the addition of two free oxygens to form the 1,2-Dioxane bridge and a peroxide functional group to form Prostaglandin G2. Second, COX-2 reduces the peroxide functional group to a Secondary alcohol, forming Prostaglandin H2. Other peroxidases like Hydroquinone have been observed to reduce PGG2 to PGH2. PGH2 is unstable at room temperature, with a half life of 90-100 seconds, so it is often converted into a different prostaglandin. (en)
- La prostaglandine H2 (PGH2) est un précurseur des prostaglandines chez les vertébrés, dérivé de l'acide arachidonique en deux étapes par des cyclooxygénases. Elle augmente l'inflammation et régule la sécrétion du suc gastrique. L'action anti-inflammatoire de l'acide acétylsalicylique (aspirine) est due à l'inhibition de la cyclooxygénase-1. La PGH2 est notamment le substrat des enzymes suivantes, qui conduisent à divers composés biochimiques physiologiquement importants : (fr)
- A Prostaglandina H2 (PGH2) é um mediador lipídico derivado do ácido araquidónico, da família das Prostaglandinas, um sub-grupo dos Eicosanóides. É sintetizada a partir da PGG2 pela enzima ciclo-oxigenase (COX), também denominada de prostaglandina H sintetase. É um dos compostos da via metabólica da cascata do ácido araquidónico e, como tal, é um importante mediador de vários processos fisiológicos e patológicos. No contexto da cascata do ácido araquidónico é precursora de uma série de moléculas biologicamente relevantes: (pt)
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- Prostaglandin H2 (de)
- Prostaglandine H2 (fr)
- Prostaglandina H2 (it)
- Prostaglandin H2 (en)
- Prostaglandina H2 (pt)
- 前列腺素H2 (zh)
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