PREDIMED (Prevención con Dieta Mediterránea (Prevention with Mediterranean Diet)) was a large Spanish primary prevention trial which included 7,447 Spanish participants (55–80 years, 58% women) who were at high risk for cardiovascular disease, but otherwise healthy (initially free of cardiovascular disease). They were randomly assigned to receive interventions with intensive education to one of three diets: 1. * Mediterranean diet supplemented with extra-virgin olive oil. 2. * Mediterranean diet supplemented with nuts. 3. * Control diet encouraging low-fat food items.
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