About: Penicillium parvum

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Penicillium parvum is an anamorph species of fungus in the genus Penicillium which was isolated from soil in Papua New Guinea. Penicillium parvum produces ferrichrome siderophores Phytochemical investigation of the soil microfungus Eupenicillum parvum led to the isolation of two new compounds: a chromone derivative euparvione and a new mycophenolic derivative euparvilactone, as well as thirteen known compounds. Several isolated compounds were evaluated for in vitro binding assays using opioid receptors (subtypes δ, κ, and μ) and cannabinoid receptors (CB1 and CB2). Compound 10 displayed the best selective μ-opioid receptor and CB1 receptor binding affinities showing values of 47% and 52% at a 10 μM concentration, respectively. These findings provide insight into the potential therapeutic u

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dbo:abstract
  • Penicillium parvum is an anamorph species of fungus in the genus Penicillium which was isolated from soil in Papua New Guinea. Penicillium parvum produces ferrichrome siderophores Phytochemical investigation of the soil microfungus Eupenicillum parvum led to the isolation of two new compounds: a chromone derivative euparvione and a new mycophenolic derivative euparvilactone, as well as thirteen known compounds. Several isolated compounds were evaluated for in vitro binding assays using opioid receptors (subtypes δ, κ, and μ) and cannabinoid receptors (CB1 and CB2). Compound 10 displayed the best selective μ-opioid receptor and CB1 receptor binding affinities showing values of 47% and 52% at a 10 μM concentration, respectively. These findings provide insight into the potential therapeutic utility of this class of compounds. (en)
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  • 47075356 (xsd:integer)
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  • 4358 (xsd:nonNegativeInteger)
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  • 1008803064 (xsd:integer)
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dbp:authority
  • Raper, K.B.; Fennell, D.I. 1948 (en)
dbp:genus
  • Penicillium (en)
dbp:species
  • parvum (en)
dbp:synonyms
  • Eupenicillium papuanum (en)
  • Penicillium papuaneum (en)
  • Carpenteles parvum, (en)
  • Eupenicillium parvum, (en)
  • Penicillium papuanum, (en)
dbp:typeStrain
  • ATCC 10479, CBS 359.48, CSIR 740, FRR 2095, IFO 7732, IMI 040587, NBRC 7732, NRRL 2095, NRRL A-809, QM 1878 (en)
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  • Penicillium parvum is an anamorph species of fungus in the genus Penicillium which was isolated from soil in Papua New Guinea. Penicillium parvum produces ferrichrome siderophores Phytochemical investigation of the soil microfungus Eupenicillum parvum led to the isolation of two new compounds: a chromone derivative euparvione and a new mycophenolic derivative euparvilactone, as well as thirteen known compounds. Several isolated compounds were evaluated for in vitro binding assays using opioid receptors (subtypes δ, κ, and μ) and cannabinoid receptors (CB1 and CB2). Compound 10 displayed the best selective μ-opioid receptor and CB1 receptor binding affinities showing values of 47% and 52% at a 10 μM concentration, respectively. These findings provide insight into the potential therapeutic u (en)
rdfs:label
  • Penicillium parvum (en)
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