An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

1-(1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptors, while antagonizing the 5-HT2A, 5-HT2B, and 5-HT2C receptors. It has also been shown to possess high affinity for the 5-HT3, 5-HT5A, 5-HT6, and 5-HT7 receptors, and may bind to 5-HT4 and the SERT as well. In animals it produces effects including hyperphagia, hyperactivity, and anxiolysis, of which are all likely mediated predominantly or fully by blockade of the 5-HT2C receptor.

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dbo:abstract
  • 1-(1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptors, while antagonizing the 5-HT2A, 5-HT2B, and 5-HT2C receptors. It has also been shown to possess high affinity for the 5-HT3, 5-HT5A, 5-HT6, and 5-HT7 receptors, and may bind to 5-HT4 and the SERT as well. In animals it produces effects including hyperphagia, hyperactivity, and anxiolysis, of which are all likely mediated predominantly or fully by blockade of the 5-HT2C receptor. (en)
dbo:casNumber
  • 57536-86-4
dbo:fdaUniiCode
  • FJ7MR37A24
dbo:pubchem
  • 1342
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dbp:alt
  • Ball-and-stick model of the naphthylpiperazine molecule (en)
  • Skeletal formula of naphthylpiperazine (en)
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  • none (en)
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  • 14 (xsd:integer)
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  • 57536 (xsd:integer)
dbp:chemspiderid
  • 1302 (xsd:integer)
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  • 16 (xsd:integer)
dbp:image
  • Naphthylpiperazine-3D-balls.png (en)
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  • 1 (xsd:integer)
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  • 3 (xsd:integer)
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  • Uncontrolled (en)
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  • 2 (xsd:integer)
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  • 1342 (xsd:integer)
dbp:routesOfAdministration
  • Oral (en)
dbp:smiles
  • c2ccN3CCNCC3 (en)
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  • FJ7MR37A24 (en)
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  • 125 (xsd:integer)
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  • 1-(1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F receptors, while antagonizing the 5-HT2A, 5-HT2B, and 5-HT2C receptors. It has also been shown to possess high affinity for the 5-HT3, 5-HT5A, 5-HT6, and 5-HT7 receptors, and may bind to 5-HT4 and the SERT as well. In animals it produces effects including hyperphagia, hyperactivity, and anxiolysis, of which are all likely mediated predominantly or fully by blockade of the 5-HT2C receptor. (en)
rdfs:label
  • Naphthylpiperazine (en)
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