Sultan Mudafar Syah I (b. c. 1595–d. 16 June 1627), also spelt Muzaffar Syah, was the ninth Sultan of Ternate who ruled from 1606 to 1627. He reigned during an important transitional phase, when the Dutch East India Company gained ascendency in the Maluku Islands and began to regulate the commerce in spices. This was the beginning of the colonial subordination of Maluku that would accelerate during his successors.