Malcolm Dixon (1899 - 1985) was a British biochemist. He studied physical biochemistry, especially the purification of enzymes and the kinetics of enzyme-catalyzed reactions. He studied the oxidation of glutathione and other thiols by molecular oxygen and measured the redox potential of the thiol-disulfide system, also establishing that the oxidation of glutathione was catalyzed by trace metals.

PropertyValue
p:abstract
  • Malcolm Dixon (1899 - 1985) was a British biochemist. He studied physical biochemistry, especially the purification of enzymes and the kinetics of enzyme-catalyzed reactions. He studied the oxidation of glutathione and other thiols by molecular oxygen and measured the redox potential of the thiol-disulfide system, also establishing that the oxidation of glutathione was catalyzed by trace metals. He investigated xanthine oxidase, and thereby established many aspects of the chemistry of dehydrogenases. He showed that the hydrogen peroxide formed in the reaction of xanthine oxidase with molecular oxygen inactivated the enzyme and that the inhibition could be relieved by the addition of catalase, thus helping to establish a biochemical role for the latter enzyme. Dixon published a series of papers on D-amino acid oxidase, detailing the kinetics and thermodynamics of association of the coenzyme with the apoprotein, the substrate and inhibitor specificity, and the effect of pH on the kinetic constants. He was an expert on the theory and use of manometers In 1931, he collaborated with Keilin and Hill to determine the first absorption spectrum of a cytochrome, cytochrome c. Dixon studied the chemistry of lachrymators and mustard gas and proposed a phosphokinase theory to explain their mode of action. He received his PhD in 1925, under Frederick Gowland Hopkins at the University of Cambridge." (en)
p:almaMater
p:birthDate
  • 1899-04-18 (xsd:date)
p:birthPlace
p:boxWidth
  • 300px (en)
p:caption
  • Malcolm Dixon (1899 - 1985) (en)
p:deathDate
p:deathPlace
p:doctoralAdvisor
p:field
p:hasPhotoCollection
p:imageWidth
  • 175px (en)
p:name
  • Malcolm Dixon (en)
p:nationality
p:religion
p:residence
p:wikiPageUsesTemplate
p:wordnet_type
p:workInstitutions
rdfs:comment
  • Malcolm Dixon (1899 - 1985) was a British biochemist. He studied physical biochemistry, especially the purification of enzymes and the kinetics of enzyme-catalyzed reactions. He studied the oxidation of glutathione and other thiols by molecular oxygen and measured the redox potential of the thiol-disulfide system, also establishing that the oxidation of glutathione was catalyzed by trace metals. (en)
rdfs:label
  • Malcolm Dixon (en)
foaf:depiction
foaf:img
foaf:page
p:doctoralAdvisor
p:doctoralStudents
owl:sameAs
Powered by OpenLink Virtuoso