Isabella Macdonald (née Clark; 1809 – 28 December 1857) was the first wife of John A. Macdonald, one of the fathers of the Canadian federation, and ultimately the first Prime Minister of Canada. After marrying Macdonald in Kingston, Ontario in 1843, she enjoyed two years of happy marriage before falling seriously ill. Her first son died at 13 months but her second son, Hugh John Macdonald, became Premier of Manitoba. Despite some better spells, she died aged 48, never recovering from her illness.
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