About: H3S10P

An Entity of Type: Thing, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

H3S10P is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the phosphorylation the 10th serine residue of the histone H3 protein. Depending on the environment in which it happens, the same phosphorylated residue might have drastically different consequences on chromatin structure. H3S10 and H3S28 phosphorylation is an excellent illustration of this duality: both phosphorylated residues are involved in chromatin compaction during mitosis and meiosis, as well as chromatin relaxation after transcription activation. Because of the diverse roles that these phosphorylation events play, individual residue phosphorylation can't be examined in isolation. The impact is determined by the cellular environment and interplay with other cis or trans changes.

Property Value
dbo:abstract
  • H3S10P is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the phosphorylation the 10th serine residue of the histone H3 protein. Depending on the environment in which it happens, the same phosphorylated residue might have drastically different consequences on chromatin structure. H3S10 and H3S28 phosphorylation is an excellent illustration of this duality: both phosphorylated residues are involved in chromatin compaction during mitosis and meiosis, as well as chromatin relaxation after transcription activation. Because of the diverse roles that these phosphorylation events play, individual residue phosphorylation can't be examined in isolation. The impact is determined by the cellular environment and interplay with other cis or trans changes. The S10 phosphorylation is involved in mitosis, transcription, chromatin condensation, and UVB response. H3S10p causes chromosome condensation and segregation during cell mitosis. H3S10p temporarily increases during mitosis while H3K9me3 decareses and H3K9me3 recovers upon mitotic exit. R loops are linked to H3S10P and chromatin condensation. (en)
dbo:wikiPageID
  • 70513413 (xsd:integer)
dbo:wikiPageLength
  • 25961 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1085679459 (xsd:integer)
dbo:wikiPageWikiLink
dbp:wikiPageUsesTemplate
dcterms:subject
rdfs:comment
  • H3S10P is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the phosphorylation the 10th serine residue of the histone H3 protein. Depending on the environment in which it happens, the same phosphorylated residue might have drastically different consequences on chromatin structure. H3S10 and H3S28 phosphorylation is an excellent illustration of this duality: both phosphorylated residues are involved in chromatin compaction during mitosis and meiosis, as well as chromatin relaxation after transcription activation. Because of the diverse roles that these phosphorylation events play, individual residue phosphorylation can't be examined in isolation. The impact is determined by the cellular environment and interplay with other cis or trans changes. (en)
rdfs:label
  • H3S10P (en)
owl:sameAs
prov:wasDerivedFrom
foaf:isPrimaryTopicOf
is dbo:wikiPageRedirects of
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License