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- In enzymology, a glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) is an enzyme that catalyzes the chemical reaction tetradecanoyl-CoA + glycylpeptide CoA + N-tetradecanoylglycylpeptide Thus, the two substrates of this enzyme are and , whereas its two products are CoA and . It participates in the N-Myristoylation of proteins, and in vertebrates there are two isoenzymes NMT1 and NMT2. Besides tetradecanoyl-CoA, this enzyme is also capable of using modified versions of this substrate. In human retina, an even wider range of fatty acids, including 14:1 n–9, 14:2n–6, and 12:0, are accepted by the enzyme and grafted onto guanylate cyclase activators. This is mainly a result of a special set of fatty-acid-CoA substrates available in the retina. (en)
- La glicilpeptide N-tetradecanoiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione: tetra + glicilpeptide ⇄ CoA + N-tetradecanoilglicilpeptide L'enzima del lievito è altamente specifico per il tetradecanoil-CoA, ed anche per la glicina N-terminale negli oligopeptidi contenenti serina alla posizione 5. L'enzima del cuore dei mammiferi trasferisce gruppi acilici ad una specifica proteina accettore di 51 kDa. (it)
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- 4223 (xsd:nonNegativeInteger)
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- Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA. Myristoyl-CoA . PDB ID: 3IU1 (en)
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- IPR022677 (en)
- IPR022676 (en)
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| dbp:name
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- NMT, C-terminal (en)
- NMT, N-terminal (en)
- glycylpeptide N-tetradecanoyltransferase (en)
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- PF02799 (en)
- PF01233 (en)
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| rdfs:comment
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- La glicilpeptide N-tetradecanoiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione: tetra + glicilpeptide ⇄ CoA + N-tetradecanoilglicilpeptide L'enzima del lievito è altamente specifico per il tetradecanoil-CoA, ed anche per la glicina N-terminale negli oligopeptidi contenenti serina alla posizione 5. L'enzima del cuore dei mammiferi trasferisce gruppi acilici ad una specifica proteina accettore di 51 kDa. (it)
- In enzymology, a glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) is an enzyme that catalyzes the chemical reaction tetradecanoyl-CoA + glycylpeptide CoA + N-tetradecanoylglycylpeptide Thus, the two substrates of this enzyme are and , whereas its two products are CoA and . It participates in the N-Myristoylation of proteins, and in vertebrates there are two isoenzymes NMT1 and NMT2. (en)
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- Glycylpeptide N-tetradecanoyltransferase (en)
- Glicilpeptide N-tetradecanoiltransferasi (it)
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- glycylpeptide N-tetradecanoyltransferase (en)
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