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In the Gallagher–Hollander degradation (1946) pyruvic acid is removed from a linear aliphatic carboxylic acid yielding a new acid with two carbon atoms fewer. The original publication concerns the conversion of bile acid in a series of reactions: acid chloride (2) formation with thionyl chloride, formation (3) with diazomethane, chloromethyl ketone formation (4) with hydrochloric acid, organic reduction of chlorine to methylketone (5), ketone halogenation to 6, elimination reaction with pyridine to enone 7 and finally oxidation with chromium trioxide to bisnorcholanic acid 8.

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  • In the Gallagher–Hollander degradation (1946) pyruvic acid is removed from a linear aliphatic carboxylic acid yielding a new acid with two carbon atoms fewer. The original publication concerns the conversion of bile acid in a series of reactions: acid chloride (2) formation with thionyl chloride, formation (3) with diazomethane, chloromethyl ketone formation (4) with hydrochloric acid, organic reduction of chlorine to methylketone (5), ketone halogenation to 6, elimination reaction with pyridine to enone 7 and finally oxidation with chromium trioxide to bisnorcholanic acid 8. (en)
  • La Degradación de Gallagher-Hollander (1946) es un método de síntesis orgánica en donde el ácido pirúvico se remueve de un ácido carboxílico alifático lineal produciendo un ácido nuevo con dos átomos de carbono menos.​ La publicación original se refiere a la conversión de ácidos biliares en una serie de reacciones: 1) La formación del (2) con cloruro de tionilo.2) La formación de la (3) con diazometano.3) La formación de la clorometilcetona (4) con ácido clorhídrico.4) La reducción con cloro a la metilcetona (5)5) La halogenación de la cetona a (6)6) La reacción de eliminación con piridina a la enona 77) La oxidación con trióxido de cromo para dar el ácido bisnorcolánico. (es)
  • 加拉格尔-霍兰德降解反应(Gallagher-Hollander degradation)於1946年報導,是将直链脂肪族羧酸为少两个碳的羧酸的方法。 原始方法是通过一系列反应将胆汁酸(1)降解为bisnorcholanic acid (8)。过程为: (1) 与亚硫酰氯反应生成酰氯(2);(2) 用重氮甲烷处理得到(3);(3) 用盐酸处理生成α-(4);(4) 用锌/乙酸还原为甲基酮(5);(5) 发生α-溴化生成溴代酮(6);(6) 在吡啶中消除溴化氢得到(7);(7) 最后(7)用三氧化铬氧化,发生C–C键断裂,得(8)。 (zh)
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  • In the Gallagher–Hollander degradation (1946) pyruvic acid is removed from a linear aliphatic carboxylic acid yielding a new acid with two carbon atoms fewer. The original publication concerns the conversion of bile acid in a series of reactions: acid chloride (2) formation with thionyl chloride, formation (3) with diazomethane, chloromethyl ketone formation (4) with hydrochloric acid, organic reduction of chlorine to methylketone (5), ketone halogenation to 6, elimination reaction with pyridine to enone 7 and finally oxidation with chromium trioxide to bisnorcholanic acid 8. (en)
  • 加拉格尔-霍兰德降解反应(Gallagher-Hollander degradation)於1946年報導,是将直链脂肪族羧酸为少两个碳的羧酸的方法。 原始方法是通过一系列反应将胆汁酸(1)降解为bisnorcholanic acid (8)。过程为: (1) 与亚硫酰氯反应生成酰氯(2);(2) 用重氮甲烷处理得到(3);(3) 用盐酸处理生成α-(4);(4) 用锌/乙酸还原为甲基酮(5);(5) 发生α-溴化生成溴代酮(6);(6) 在吡啶中消除溴化氢得到(7);(7) 最后(7)用三氧化铬氧化,发生C–C键断裂,得(8)。 (zh)
  • La Degradación de Gallagher-Hollander (1946) es un método de síntesis orgánica en donde el ácido pirúvico se remueve de un ácido carboxílico alifático lineal produciendo un ácido nuevo con dos átomos de carbono menos.​ La publicación original se refiere a la conversión de ácidos biliares en una serie de reacciones: (es)
rdfs:label
  • Degradación de Gallagher-Hollander (es)
  • Gallagher–Hollander degradation (en)
  • 加拉格尔-霍兰德降解反应 (zh)
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