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Fluorination by sulfur tetrafluoride produces organofluorine compounds from oxidized organic compounds, including alcohols, carbonyl compounds, alkyl halides, and others. Sulfur tetrafluoride is a gaseous reagent that may be used to fluorinate a variety of organic functional groups, including carbonyl compounds, alcohols, and halides. Treatment of carbonyl compounds generally converts them into organofluorides of equivalent oxidation state: carboxylic acids are converted to trifluoromethyl compounds, ketones and aldehydes to difluorides, etc. The reaction has broad scope and is one of the few methods available for the direct introduction of fluorine at a specific site under relatively mild conditions.

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  • Fluorination by sulfur tetrafluoride produces organofluorine compounds from oxidized organic compounds, including alcohols, carbonyl compounds, alkyl halides, and others. Sulfur tetrafluoride is a gaseous reagent that may be used to fluorinate a variety of organic functional groups, including carbonyl compounds, alcohols, and halides. Treatment of carbonyl compounds generally converts them into organofluorides of equivalent oxidation state: carboxylic acids are converted to trifluoromethyl compounds, ketones and aldehydes to difluorides, etc. The reaction has broad scope and is one of the few methods available for the direct introduction of fluorine at a specific site under relatively mild conditions. (1) Fluorinations of alcohols and halides are also possible with SF4. However, SF4 is gaseous at room temperature, and many transformations involving this reagent require elevated temperatures, making handling somewhat difficult. In addition, the reaction generates large amounts of hydrogen fluoride. These concerns have led to the development of safer, more robust fluorinating reagents, such as DAST (diethylaminosulfur trifluoride). (en)
  • 四氟化硫氟化法是用于将含氧或含其他卤素的有机化合物转化为有机氟化物的方法。 四氟化硫是一种气态氟化试剂,可以氟化羰基、醇、其他卤素等多种官能团。羰基化合物通常会被转化为相同氧化态的有机氟化物:例如羧酸氟化生成三氟甲基化合物,醛酮则生成偕二氟化物。该反应适用范围较广,是少数可在相对温和的条件下即可在特定位点直接氟化的方法之一。 (1) 醇与其他卤化物也可以用SF4进行氟化。但是,SF4在室温下为气态,而进行氟化时往往又要求升温,这使得反应处理有些困难。此外,SF4进行氟化时会产生大量氟化氢。这些问题使得人们开发了更加安全、稳定的氟化试剂,例如DAST (二乙氨基三氟化硫 )。 (zh)
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  • 四氟化硫氟化法是用于将含氧或含其他卤素的有机化合物转化为有机氟化物的方法。 四氟化硫是一种气态氟化试剂,可以氟化羰基、醇、其他卤素等多种官能团。羰基化合物通常会被转化为相同氧化态的有机氟化物:例如羧酸氟化生成三氟甲基化合物,醛酮则生成偕二氟化物。该反应适用范围较广,是少数可在相对温和的条件下即可在特定位点直接氟化的方法之一。 (1) 醇与其他卤化物也可以用SF4进行氟化。但是,SF4在室温下为气态,而进行氟化时往往又要求升温,这使得反应处理有些困难。此外,SF4进行氟化时会产生大量氟化氢。这些问题使得人们开发了更加安全、稳定的氟化试剂,例如DAST (二乙氨基三氟化硫 )。 (zh)
  • Fluorination by sulfur tetrafluoride produces organofluorine compounds from oxidized organic compounds, including alcohols, carbonyl compounds, alkyl halides, and others. Sulfur tetrafluoride is a gaseous reagent that may be used to fluorinate a variety of organic functional groups, including carbonyl compounds, alcohols, and halides. Treatment of carbonyl compounds generally converts them into organofluorides of equivalent oxidation state: carboxylic acids are converted to trifluoromethyl compounds, ketones and aldehydes to difluorides, etc. The reaction has broad scope and is one of the few methods available for the direct introduction of fluorine at a specific site under relatively mild conditions. (en)
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  • Fluorination by sulfur tetrafluoride (en)
  • 四氟化硫氟化法 (zh)
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