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- The Debus–Radziszewski imidazole synthesis is an organic reaction used for the synthesis of imidazoles from a dicarbonyl, an aldehyde, and ammonia. The dicarbonyl component is commonly glyoxal, but can also include various 1,2-diketones and ketoaldehydes. The method is used commercially to produce several imidazoles. The process is an example of a multicomponent reaction. The reaction can be viewed as occurring in two stages. In the first stage, the dicarbonyl and ammonia condense to give a diimine (shown with unusual orientation of N-H groups): In the second stage, this diimine condenses with the aldehyde: This reaction is named after Heinrich Debus and Bronisław Leonard Radziszewski. A modification of this general method, where one equivalent of ammonia is replaced by an amine, affords N-substituted imidazoles in good yields. (en)
- Die Radziszewski-Synthese ist eine Namensreaktion der Organischen Chemie und benannt nach dem polnischen Chemiker Bronisław Leonard Radziszewski (1838–1914). Sie beschreibt die Darstellung von Imidazol und dessen Derivaten. Zu diesem Zweck wird ein 1,2-Diketon mit Ammoniak und einem Aldehyd umgesetzt. (de)
- Debus–Radziszewski咪唑合成（Debus–Radziszewski imidazole synthesis） 以二酮、醛和氨为原料合成咪唑衍生物。 反应中首先是二酮与氨失水缩合为二元亚胺， 然后二元亚胺与醛缩合，得咪唑环。 反应以化学家 Heinrich Debus 和 Bronisław Leonard Radziszewski 的名字命名。 (zh)
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- Debus–Radziszewski imidazole synthesis (en)
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- Ring forming reaction (en)
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- Die Radziszewski-Synthese ist eine Namensreaktion der Organischen Chemie und benannt nach dem polnischen Chemiker Bronisław Leonard Radziszewski (1838–1914). Sie beschreibt die Darstellung von Imidazol und dessen Derivaten. Zu diesem Zweck wird ein 1,2-Diketon mit Ammoniak und einem Aldehyd umgesetzt. (de)
- Debus–Radziszewski咪唑合成（Debus–Radziszewski imidazole synthesis） 以二酮、醛和氨为原料合成咪唑衍生物。 反应中首先是二酮与氨失水缩合为二元亚胺， 然后二元亚胺与醛缩合，得咪唑环。 反应以化学家 Heinrich Debus 和 Bronisław Leonard Radziszewski 的名字命名。 (zh)
- The Debus–Radziszewski imidazole synthesis is an organic reaction used for the synthesis of imidazoles from a dicarbonyl, an aldehyde, and ammonia. The dicarbonyl component is commonly glyoxal, but can also include various 1,2-diketones and ketoaldehydes. The method is used commercially to produce several imidazoles. The process is an example of a multicomponent reaction. The reaction can be viewed as occurring in two stages. In the first stage, the dicarbonyl and ammonia condense to give a diimine (shown with unusual orientation of N-H groups): (en)
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- Debus–Radziszewski imidazole synthesis (en)
- Radziszewski-Synthese (de)
- Debus–Radziszewski咪唑合成 (zh)
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