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- In enzymology, a sterol 14-demethylase (EC 1.14.13.70) is an enzyme of the Cytochrome P450 (CYP) superfamily. It is any member of the CYP51 family. It catalyzes a chemical reaction such as: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 3 NADP+ + 4 H2O The 4 substrates here are obtusifoliol, O2, NADPH, and H+, whereas its 4 products are , formate, NADP+, and H2O. Although the lanosterol 14α-demethylase is present in a wide variety of organisms, the enzyme is studied primarily in the context of fungi, where it plays an essential role in mediating membrane permeability. In fungi, CYP51 catalyzes the demethylation of lanosterol to create an important precursor that is eventually converted into ergosterol. This steroid then makes its way throughout the cell, where it alters the permeability and rigidity of plasma membranes much as cholesterol does in animals. Because ergosterol constitutes a fundamental component of fungal membranes, many antifungal medications have been developed to inhibit 14α-demethylase activity and prevent the production of this key compound. (en)
- La sterolo 14-demetilasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: + 3 O2 + 3 NADPH + 3 H+ ⇄ 4α-metil-5α-ergosta-8,14,24(28)-trien-3β-olo + formato + 3 NADP+ + 4 H2O L'enzima è una proteina eme-tiolata (P-450) che catalizza le successive idrossilazioni del gruppo 14α-metile e del C-15, seguite dall'eliminazione del formato, lasciando il doppio legame 14(15).Questo enzima agisce un ampio raggio di steroidi con un gruppo 14α-metile.La classe antimicotica degli azoli utilizzata per le infezioni sistemiche inibisce questo enzima rendendo quindi impossibile la sintesi dell'ergosterolo. (it)
- ステロール-14-デメチラーゼ（sterol 14-demethylase）は、ステロイド合成酵素の一つ。次の化学反応を触媒する酸化還元酵素である。 ステロイド合成経路において、オキシドスクアレン環化によるプロトステロール形成後の修飾に関与する。この酵素の基質はとNADPH、H+およびO2で、生成物はとNADP+、ギ酸、H2Oである。 組織名はsterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)で、別名にobtusufoliol 14-demethylase、lanosterol 14-demethylase、lanosterol 14α-demethylase、sterol 14α-demethylaseがある。 (ja)
- Esterol 14-demetilase é uma enzima que catalisa a reação química: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formiato + 3 NADP+ + 4 H2O. Os quatro substratos desta enzima são o , O2, NADPH, e H+, e os quatro produtos são , formiato, NADP+, e H2O. Esta enzima pertence a família das e participa na . (pt)
- 细胞色素P450家族51，CYP51也称为甾醇-14-去甲基酶（英語：sterol 14-demethylase，EC 1.14.13.70）是催化一系列14α-甲基甾醇去甲基化的酶。多种C29、C30甾醇底物可被CYP51家族的酶去甲基化，如CYP51F1主要催化： 钝叶醇 + 3 O2 + 3 NADPH + 3 H+ 4α-甲基-5α-麦角甾-8,14,24(28)-三烯-3β-ol + 甲酸 + 3 NADP+ + 4 H2O 而CYP51A1在人体内催化2,3-环氧鲨烯环化为羊毛甾醇后的第一步反应： 羊毛甾醇 + 3 O2 + 3 NADPH + 3 H+ 4,4-二甲基-5α-胆甾-8(9),14,24-三烯-3β-ol + 甲酸 + 3 NADP+ + 4 H2O (zh)
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- sterol 14-demethylase (en)
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- ステロール-14-デメチラーゼ（sterol 14-demethylase）は、ステロイド合成酵素の一つ。次の化学反応を触媒する酸化還元酵素である。 ステロイド合成経路において、オキシドスクアレン環化によるプロトステロール形成後の修飾に関与する。この酵素の基質はとNADPH、H+およびO2で、生成物はとNADP+、ギ酸、H2Oである。 組織名はsterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)で、別名にobtusufoliol 14-demethylase、lanosterol 14-demethylase、lanosterol 14α-demethylase、sterol 14α-demethylaseがある。 (ja)
- Esterol 14-demetilase é uma enzima que catalisa a reação química: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formiato + 3 NADP+ + 4 H2O. Os quatro substratos desta enzima são o , O2, NADPH, e H+, e os quatro produtos são , formiato, NADP+, e H2O. Esta enzima pertence a família das e participa na . (pt)
- 细胞色素P450家族51，CYP51也称为甾醇-14-去甲基酶（英語：sterol 14-demethylase，EC 1.14.13.70）是催化一系列14α-甲基甾醇去甲基化的酶。多种C29、C30甾醇底物可被CYP51家族的酶去甲基化，如CYP51F1主要催化： 钝叶醇 + 3 O2 + 3 NADPH + 3 H+ 4α-甲基-5α-麦角甾-8,14,24(28)-三烯-3β-ol + 甲酸 + 3 NADP+ + 4 H2O 而CYP51A1在人体内催化2,3-环氧鲨烯环化为羊毛甾醇后的第一步反应： 羊毛甾醇 + 3 O2 + 3 NADPH + 3 H+ 4,4-二甲基-5α-胆甾-8(9),14,24-三烯-3β-ol + 甲酸 + 3 NADP+ + 4 H2O (zh)
- In enzymology, a sterol 14-demethylase (EC 1.14.13.70) is an enzyme of the Cytochrome P450 (CYP) superfamily. It is any member of the CYP51 family. It catalyzes a chemical reaction such as: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 3 NADP+ + 4 H2O The 4 substrates here are obtusifoliol, O2, NADPH, and H+, whereas its 4 products are , formate, NADP+, and H2O. (en)
- La sterolo 14-demetilasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: + 3 O2 + 3 NADPH + 3 H+ ⇄ 4α-metil-5α-ergosta-8,14,24(28)-trien-3β-olo + formato + 3 NADP+ + 4 H2O (it)
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- Sterol 14-demethylase (en)
- Sterolo 14-demetilasi (it)
- ステロール-14-デメチラーゼ (ja)
- Esterol 14-demetilase (pt)
- CYP51 (zh)
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- sterol 14-demethylase (en)
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