Copenhagen disease, sometimes known as Copenhagen syndrome or progressive non-infectious anterior vertebral fusion (PAVF), is a unique spinal disorder with distinctive radiological features. This is a rare childhood disease of unknown cause, affecting females slightly more than males (60%). Prevalence is unknown, but there have been approximately 80–100 individuals with Copenhagen disease reported since 1949. However, there is still little known research due to the rarity of the disease. The disease is so rare that the National Organization for Rare Diseases does not even mention Copenhagen disease in their database.
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