About: Case series

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A case series (also known as a clinical series) is a type of medical research study that tracks subjects with a known exposure, such as patients who have received a similar treatment, or examines their medical records for exposure and outcome. Case series may be consecutive or non-consecutive, depending on whether all cases presenting to the reporting authors over a period were included, or only a selection. When information on more than three patients is included, the case series is considered to be a systematic investigation designed to contribute to generalizable knowledge (i.e., research), and therefore submission is required to an institutional review board (IRB). Case series usually contain demographic information about the patient(s), for example, age, gender, ethnic origin. etc.

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  • Eine Fallserie ist eine Art von Beobachtungsstudie in der Medizin. Bei ihr wird eine Gruppe von Patienten mit einer bestimmten Krankheit betrachtet, ohne dass dabei im Rahmen der Studie spezielle Maßnahmen, wie z. B. eine studienspezifische Therapie, erfolgen (nicht-interventionelle Studie). Fallserien haben die niedrigste Evidenzklasse der evidenzbasierten Medizin. Zum Beispiel bei seltenen Krankheiten, die mit randomisierten kontrollierten Studien nicht untersucht werden können, sind sie aber mitunter das beste Mittel, um die Wirksamkeit einer Maßnahme zu beurteilen. Fallserien lassen sich unterteilen in retrospektiv und prospektiv zusammengestellte. Bei retrospektiv zusammengestellten Fallserien stellt sich die Frage nach der Vergleichbarkeit von z. B. Diagnosekriterien, während solche Aspekte bei prospektiven Studien vorab festgelegt werden können. (de)
  • A case series (also known as a clinical series) is a type of medical research study that tracks subjects with a known exposure, such as patients who have received a similar treatment, or examines their medical records for exposure and outcome. Case series may be consecutive or non-consecutive, depending on whether all cases presenting to the reporting authors over a period were included, or only a selection. When information on more than three patients is included, the case series is considered to be a systematic investigation designed to contribute to generalizable knowledge (i.e., research), and therefore submission is required to an institutional review board (IRB). Case series usually contain demographic information about the patient(s), for example, age, gender, ethnic origin. etc. Case series have a descriptive study design; unlike studies that employ an analytic design (e.g. cohort studies, case-control studies or randomized controlled trials), case series do not, in themselves, involve hypothesis testing to look for evidence of cause and effect (though analyses are sometimes performed in genetic epidemiology to investigate the association between an exposure and a genotype). Case series are especially vulnerable to selection bias; for example, studies that report on a series of patients with a certain illness and/or a suspected linked exposure draw their patients from a particular population (such as a hospital or clinic) which may not appropriately represent the wider population. Internal validity of case series studies is usually very low, due to the lack of a comparator group exposed to the same array of intervening variables. For example, the effects seen may be wholly or partly due to intervening effects such as the placebo effect, Hawthorne effect, Rosenthal effect, time effects, practice effects or the natural history effect. Calculating the difference in effects between two treatment groups assumed to be exposed to a very similar array of such intervening effects allows the effects of these intervening variables to cancel out. Hence only the presence of a comparator group, which is not a feature of case-series studies, will allow a valid estimate of the true treatment effect. (en)
  • Un estudio de serie de casos clínicos (o situaciones de cualquier tipo que estén relacionados con la investigación científica, industrial, académica, etc.) es un estudio epidemiológico, descriptivo, que se limita a la simple identificación y descripción de un conjunto de casos clínicos que han aparecido en un intervalo de tiempo. En el caso de nuevas enfermedades o fármacos, las series de casos contribuyen a la caracterización del perfil y delimitación de nuevas entidades nosológicas. Sin embargo, para valorar la importancia de los antecedentes y posibles asociaciones es necesaria la presencia de un grupo control que sirva de referencia y comparación. (es)
  • Uma série de casos é uma forma de estudo do tipo observacional, muito comum na pesquisa médica, que acompanha pacientes com uma exposição conhecida a um dado tratamento similar ou analisa os prontuários médicos para avaliar a relação entre exposição e desfecho. Ela pode ser retrospectiva ou prospectiva e geralmente envolve um número menor de pacientes em relação a outros desenhos de estudos mais poderosos, como o ou estudos randomizados controlados. Série de casos pode ser consecutivas ou não-consecutivas. (pt)
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  • Uma série de casos é uma forma de estudo do tipo observacional, muito comum na pesquisa médica, que acompanha pacientes com uma exposição conhecida a um dado tratamento similar ou analisa os prontuários médicos para avaliar a relação entre exposição e desfecho. Ela pode ser retrospectiva ou prospectiva e geralmente envolve um número menor de pacientes em relação a outros desenhos de estudos mais poderosos, como o ou estudos randomizados controlados. Série de casos pode ser consecutivas ou não-consecutivas. (pt)
  • A case series (also known as a clinical series) is a type of medical research study that tracks subjects with a known exposure, such as patients who have received a similar treatment, or examines their medical records for exposure and outcome. Case series may be consecutive or non-consecutive, depending on whether all cases presenting to the reporting authors over a period were included, or only a selection. When information on more than three patients is included, the case series is considered to be a systematic investigation designed to contribute to generalizable knowledge (i.e., research), and therefore submission is required to an institutional review board (IRB). Case series usually contain demographic information about the patient(s), for example, age, gender, ethnic origin. etc. (en)
  • Eine Fallserie ist eine Art von Beobachtungsstudie in der Medizin. Bei ihr wird eine Gruppe von Patienten mit einer bestimmten Krankheit betrachtet, ohne dass dabei im Rahmen der Studie spezielle Maßnahmen, wie z. B. eine studienspezifische Therapie, erfolgen (nicht-interventionelle Studie). Fallserien haben die niedrigste Evidenzklasse der evidenzbasierten Medizin. Zum Beispiel bei seltenen Krankheiten, die mit randomisierten kontrollierten Studien nicht untersucht werden können, sind sie aber mitunter das beste Mittel, um die Wirksamkeit einer Maßnahme zu beurteilen. (de)
  • Un estudio de serie de casos clínicos (o situaciones de cualquier tipo que estén relacionados con la investigación científica, industrial, académica, etc.) es un estudio epidemiológico, descriptivo, que se limita a la simple identificación y descripción de un conjunto de casos clínicos que han aparecido en un intervalo de tiempo. (es)
rdfs:label
  • Fallserie (de)
  • Case series (en)
  • Estudio de serie de casos (es)
  • Série de casos (pt)
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