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- Bevirimat (research code MPC-4326) is an anti-HIV drug derived from a betulinic acid-like compound, first isolated from Syzygium claviflorum, a Chinese herb. It is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition. It is not currently U.S. Food and Drug Administration (FDA) approved. It was originally developed by the pharmaceutical company and reached Phase IIb clinical trials. Myriad Genetics announced on January 21, 2009 the acquisition of all rights to bevirimat for $7M USD. On June 8, 2010 Myriad Genetics announced that it was halting the development of maturation inhibitors, including bevirimat, to focus more on their oncology portfolio. (en)
- Bevirimat (PA-457) ist ein experimenteller Arzneistoff, der zur Behandlung HIV-infizierter Patienten im Rahmen einer HIV-Kombinationstherapie entwickelt wird. Er gehört zur Gruppe der Maturations-Inhibitoren. (de)
- Le bevirimat, ou PA-457, est un antiviral agissant sur le virus de l'immunodéficience humaine de type 1, dont le développement clinique est actuellement arrêté. (fr)
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- 16117 (xsd:nonNegativeInteger)
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- Hepatic glucuronidation (en)
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- YJEJKUQEXFSVCJ-WRFMNRASSA-N (en)
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- PA-457; 3-O--betulinic acid (en)
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- Bevirimat (research code MPC-4326) is an anti-HIV drug derived from a betulinic acid-like compound, first isolated from Syzygium claviflorum, a Chinese herb. It is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition. It is not currently U.S. Food and Drug Administration (FDA) approved. It was originally developed by the pharmaceutical company and reached Phase IIb clinical trials. Myriad Genetics announced on January 21, 2009 the acquisition of all rights to bevirimat for $7M USD. On June 8, 2010 Myriad Genetics announced that it was halting the development of maturation inhibitors, including bevirimat, to focus more on their oncology portfolio. (en)
- Bevirimat (PA-457) ist ein experimenteller Arzneistoff, der zur Behandlung HIV-infizierter Patienten im Rahmen einer HIV-Kombinationstherapie entwickelt wird. Er gehört zur Gruppe der Maturations-Inhibitoren. (de)
- Le bevirimat, ou PA-457, est un antiviral agissant sur le virus de l'immunodéficience humaine de type 1, dont le développement clinique est actuellement arrêté. (fr)
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- Bevirimat (de)
- Bevirimat (en)
- Bevirimat (fr)
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