About: Amiflamine

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Amiflamine (FLA-336) is a reversible inhibitor of monoamine oxidase A (MAO-A), thereby being a RIMA, and, to a lesser extent, semicarbazide-sensitive amine oxidase (SSAO), as well as a serotonin releasing agent (SRA). It is a derivative of the phenethylamine and amphetamine chemical classes. The (+)-enantiomer is the active stereoisomer.

Property	Value
dbo:abstract	Amiflamine (FLA-336) is a reversible inhibitor of monoamine oxidase A (MAO-A), thereby being a RIMA, and, to a lesser extent, semicarbazide-sensitive amine oxidase (SSAO), as well as a serotonin releasing agent (SRA). It is a derivative of the phenethylamine and amphetamine chemical classes. The (+)-enantiomer is the active stereoisomer. Amiflamine shows preference for inhibiting MAO-A in serotonergic relative to noradrenergic and dopaminergic neurons. In other words, at low doses, it can be used to selectively inhibit MAO-A enzymes in serotonin cells, whereas at higher doses it loses its selectivity. This property is attributed to amiflamine's higher affinity for the serotonin transporter over the norepinephrine and dopamine transporters, as transporter-mediated carriage is required for amiflamine to enter monoaminergic neurons. (en)
dbo:casNumber	77518-07-1
dbo:chEMBL	30344
dbo:fdaUniiCode	NE25WV9C8S
dbo:pubchem	71221
dbo:thumbnail	wiki-commons:Special:FilePath/Amiflamine.svg?width=300
dbo:wikiPageID	26338492 (xsd:integer)
dbo:wikiPageLength	5135 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1032988862 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Enantiomer dbr:Enzyme_inhibitor dbr:Reversible_inhibitor_of_monoamine_oxidase_A dbr:Dopamine_transporter dbr:Dopaminergic dbr:Substituted_amphetamine dbc:Serotonin_releasing_agents dbr:Neuron dbr:Monoamine_oxidase_inhibitor dbr:Stereoisomer dbc:Monoamine_oxidase_inhibitors dbc:Anilines dbc:Substituted_amphetamines dbr:Affinity_(pharmacology) dbr:Serotonergic dbr:Semicarbazide-sensitive_amine_oxidase dbr:Serotonin_releasing_agent dbr:Serotonin_transporter dbr:Substituted_phenethylamine dbr:Noradrenergic dbr:Monoamine_oxidase_A dbr:Norepinephrine_transporter dbr:Chemical_class dbr:Chemical_derivative
dbp:atcPrefix	none (en)
dbp:c	12 (xsd:integer)
dbp:casNumber	77518 (xsd:integer)
dbp:chembl	30344 (xsd:integer)
dbp:chemspiderid	64356 (xsd:integer)
dbp:h	20 (xsd:integer)
dbp:iupacName	4 (xsd:integer)
dbp:legalStatus	Uncontrolled (en)
dbp:n	2 (xsd:integer)
dbp:pubchem	71221 (xsd:integer)
dbp:routesOfAdministration	Oral (en)
dbp:smiles	NC (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	HFQMYSHATTXRTC-JTQLQIEISA-N (en)
dbp:synonyms	-4 (xsd:integer)
dbp:unii	NE25WV9C8S (en)
dbp:verifiedfields	changed (en)
dbp:verifiedrevid	454124445 (xsd:integer)
dbp:width	175 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:Monoamine_releasing_agents dbt:Phenethylamines dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:Monoamine_metabolism_modulators
dcterms:subject	dbc:Serotonin_releasing_agents dbc:Monoamine_oxidase_inhibitors dbc:Anilines dbc:Substituted_amphetamines
gold:hypernym	dbr:Inhibitor
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAnilines yago:Abstraction100002137 yago:AliphaticCompound114601294 yago:Amine114739004 yago:Aniline114754505 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:MethaneSeries114951377 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Substance100019613 umbel-rc:DrugProduct
rdfs:comment	Amiflamine (FLA-336) is a reversible inhibitor of monoamine oxidase A (MAO-A), thereby being a RIMA, and, to a lesser extent, semicarbazide-sensitive amine oxidase (SSAO), as well as a serotonin releasing agent (SRA). It is a derivative of the phenethylamine and amphetamine chemical classes. The (+)-enantiomer is the active stereoisomer. (en)
rdfs:label	Amiflamine (en)
owl:sameAs	freebase:Amiflamine yago-res:Amiflamine wikidata:Amiflamine dbpedia-sh:Amiflamine dbpedia-sr:Amiflamine https://global.dbpedia.org/id/4PKbA
prov:wasDerivedFrom	wikipedia-en:Amiflamine?oldid=1032988862&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Amiflamine.svg
foaf:isPrimaryTopicOf	wikipedia-en:Amiflamine
is dbo:wikiPageWikiLink of	dbr:List_of_adrenergic_drugs dbr:List_of_dopaminergic_drugs dbr:C12H20N2 dbr:Monoamine_oxidase_inhibitor dbr:Serotonin_releasing_agent dbr:List_of_drugs:_Am
is foaf:primaryTopic of	wikipedia-en:Amiflamine