About: Altinicline

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Altinicline (SIB-1508Y, SIB-1765F) is a drug which acts as an agonist at neural nicotinic acetylcholine receptors with high selectivity for the α4β2 subtype. It stimulates release of dopamine and acetylcholine in the brain in both rodent and primate models, and progressed as far as Phase II clinical trials for Parkinson's disease, where "no antiparkinsonian or cognitive-enhancing effects were demonstrated", although its current status is unclear.

Property	Value
dbo:abstract	Altinicline (SIB-1508Y, SIB-1765F) is a drug which acts as an agonist at neural nicotinic acetylcholine receptors with high selectivity for the α4β2 subtype. It stimulates release of dopamine and acetylcholine in the brain in both rodent and primate models, and progressed as far as Phase II clinical trials for Parkinson's disease, where "no antiparkinsonian or cognitive-enhancing effects were demonstrated", although its current status is unclear. (en)
dbo:casNumber	179120-92-4
dbo:chEMBL	111659
dbo:fdaUniiCode	RJ9V9V09VM
dbo:pubchem	3036156
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dbp:atcPrefix	None (en)
dbp:c	12 (xsd:integer)
dbp:casNumber	179120 (xsd:integer)
dbp:chembl	111659 (xsd:integer)
dbp:chemspiderid	2300234 (xsd:integer)
dbp:h	14 (xsd:integer)
dbp:iupacName	-3 (xsd:integer)
dbp:molecularWeight	186.252000 (xsd:double)
dbp:n	2 (xsd:integer)
dbp:pubchem	3036156 (xsd:integer)
dbp:smiles	c2ncccc2C1CCCN1C (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	NUPUDYKEEJNZRG-LBPRGKRZSA-N (en)
dbp:unii	RJ9V9V09VM (en)
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rdfs:comment	Altinicline (SIB-1508Y, SIB-1765F) is a drug which acts as an agonist at neural nicotinic acetylcholine receptors with high selectivity for the α4β2 subtype. It stimulates release of dopamine and acetylcholine in the brain in both rodent and primate models, and progressed as far as Phase II clinical trials for Parkinson's disease, where "no antiparkinsonian or cognitive-enhancing effects were demonstrated", although its current status is unclear. (en)
rdfs:label	Altinicline (en)
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is dbo:wikiPageWikiLink of	dbr:List_of_compounds_with_carbon_number_12 dbr:C12H14N2 dbr:6-Chloronicotine dbr:Alpha-4_beta-2_nicotinic_receptor dbr:Sonogashira_coupling dbr:List_of_drugs:_Al dbr:SIB-1508Y dbr:SIB-1765F
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