About: ADAM 17 endopeptidase

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ADAM 17 endopeptidase (EC 3.4.24.86, tumor necrosis factor alpha-converting enzyme, TACE) is an enzyme. This enzyme catalyses the following chemical reaction Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains This enzyme belongs to the peptidase family M12.

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  • ADAM 17 endopeptidase (EC 3.4.24.86, tumor necrosis factor alpha-converting enzyme, TACE) is an enzyme. This enzyme catalyses the following chemical reaction Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains This enzyme belongs to the peptidase family M12. (en)
dbo:ecNumber
  • 3.4.24.86
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  • 39361193 (xsd:integer)
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  • 1183 (xsd:nonNegativeInteger)
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  • 917329256 (xsd:integer)
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  • 151769 (xsd:integer)
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  • 3.400000 (xsd:double)
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  • 3 (xsd:integer)
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  • ADAM 17 endopeptidase (en)
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  • ADAM 17 endopeptidase (EC 3.4.24.86, tumor necrosis factor alpha-converting enzyme, TACE) is an enzyme. This enzyme catalyses the following chemical reaction Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains This enzyme belongs to the peptidase family M12. (en)
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  • ADAM 17 endopeptidase (en)
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  • ADAM 17 endopeptidase (en)
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