| dbo:abstract
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- 6′-Guanidinonaltrindole (6′-GNTI) is a κ–δ-opioid receptor selective ligand used in scientific research. With 6′-GNTI, evidence was provided for the first time that receptor oligomerization plays functional role in living organisms. 6′-GNTI is an extremely biased agonist of the κ-opioid receptor. It is a potent partial agonist of the G protein pathway but does not recruit the β-arrestin pathway. Due to its functional selectivity for the G protein pathway, 6′-GNTI functions as an antagonist of nonbiased KOR agonists on the β-arrestin pathway. It is thought that 6′-GTNI may be able to produce analgesia without dysphoria and with a lower incidence of tolerance. (en)
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| dbo:iupacName
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- N-[(4bS,8R,8aS,14bR)-7-(Cyclopropylmethyl)-1,8a-dihydroxy-5,6,7,8,8a,9,14,14b-octahydro-4,8-methano[1]benzofuro[2,3-b]pyrido[4,3-c]carbazol-12-yl]guanidine (en)
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- 3364 (xsd:nonNegativeInteger)
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- N-[-7--1,8a-dihydroxy-5,6,7,8,8a,9,14,14b-octahydro-4,8-methano[1]benzofuro[2,3-b]pyrido[4,3-c]carbazol-12-yl]guanidine (en)
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| rdfs:comment
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- 6′-Guanidinonaltrindole (6′-GNTI) is a κ–δ-opioid receptor selective ligand used in scientific research. With 6′-GNTI, evidence was provided for the first time that receptor oligomerization plays functional role in living organisms. (en)
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| rdfs:label
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- 6'-Guanidinonaltrindole (en)
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- 6′-Guanidinonaltrindole (en)
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