About: 5β-Reductase

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5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (EC 1.3.1.3, 3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase. This enzyme catalyses the following chemical reaction

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dbo:abstract
  • 5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (EC 1.3.1.3, 3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase. This enzyme catalyses the following chemical reaction (1) 5β-cholestan-3-one + NADP+ cholest-4-en-3-one + NADPH + H+(2) 17,21-dihydroxy-5β-pregnane-3,11,20-trione + NADP+ cortisone + NADPH + H+ The human enzyme efficiently acts on progesterone, 17α-hydroxyprogesterone, androstenedione, and testosterone to 5β-reduced metabolites. It can also act on aldosterone, corticosterone and cortisol, to some extent. (en)
  • Δ4-3-オキソステロイド-5β-レダクターゼ(Δ4-3-oxosteroid 5β-reductase)は、次の化学反応を触媒する酸化還元酵素である。 5β-コレスタン-3-オン + NADP+ コレスト-4-エン-3-オン + NADPH + H+ 反応式の通り、この酵素の基質はとNADP+、生成物はとNADPHとH+である。 17α,21-ジヒドロキシ-5β-プレグナン-3,11,20-トリオン + NADP+ コルチゾン + NADPH + H+ 反応式の通り、この酵素の基質はとNADP+、生成物はコルチゾンとNADPHとH+である。 組織名は5β-cholestan-3-one:NADP+ 4,5-oxidoreductaseである。 (ja)
  • La DELTA4-3-ossosteroide 5beta-reduttasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: (1) 5β-colestan-3-one + NADP+ ⇄ colest-4-en-3-one + NADPH + H+;;(2) 17,21-diidrossi-5β-pregnano-3,11,20-trione + NADP+ ⇄ cortisone + NADPH + H+ L'enzima umano catalizza efficientemente la riduzione del progesterone, androstenedione, 17α-idrossiprogesterone e testosterone a metaboliti 5β-ridotti; può anche agire sull'aldosterone, corticosterone e cortisolo, ma non con un ampio raggio[8]. Gli intermedi acidi biliari 7α,12α-diidrossi-4-colesten-3-one e 7α-idrossi-4-colesten-3-one possono agire come substrati [9]. (it)
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  • 1.3.1.3
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  • 38194300 (xsd:integer)
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  • 4656 (xsd:nonNegativeInteger)
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  • 997711912 (xsd:integer)
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  • 2604034 (xsd:integer)
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  • 1.300000 (xsd:double)
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  • 1 (xsd:integer)
dbp:name
  • Δ4-3-Oxosteroid 5β-reductase (en)
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rdfs:comment
  • Δ4-3-オキソステロイド-5β-レダクターゼ(Δ4-3-oxosteroid 5β-reductase)は、次の化学反応を触媒する酸化還元酵素である。 5β-コレスタン-3-オン + NADP+ コレスト-4-エン-3-オン + NADPH + H+ 反応式の通り、この酵素の基質はとNADP+、生成物はとNADPHとH+である。 17α,21-ジヒドロキシ-5β-プレグナン-3,11,20-トリオン + NADP+ コルチゾン + NADPH + H+ 反応式の通り、この酵素の基質はとNADP+、生成物はコルチゾンとNADPHとH+である。 組織名は5β-cholestan-3-one:NADP+ 4,5-oxidoreductaseである。 (ja)
  • 5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (EC 1.3.1.3, 3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase. This enzyme catalyses the following chemical reaction (en)
  • La DELTA4-3-ossosteroide 5beta-reduttasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: (1) 5β-colestan-3-one + NADP+ ⇄ colest-4-en-3-one + NADPH + H+;;(2) 17,21-diidrossi-5β-pregnano-3,11,20-trione + NADP+ ⇄ cortisone + NADPH + H+ (it)
rdfs:label
  • 5β-Reductase (en)
  • Delta4-3-ossosteroide 5beta-reduttasi (it)
  • Δ4-3-オキソステロイド-5β-レダクターゼ (ja)
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  • Δ4-3-Oxosteroid 5β-reductase (en)
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