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- 4-hydroxyphenylacetate 3-monooxygenase (EC 1.14.14.9) is an enzyme that catalyzes the chemical reaction 4-hydroxyphenylacetate + FADH2 + O2 3,4-dihydroxyphenylacetate + FAD + H2O This reaction is the first step in a pathway found in enteric bacteria such as Escherichia coli and soil bacteria such as Pseudomonas putida which degrades 4-hydroxyphenylacetate (4-HPA), allowing these bacteria to use 4-HPA and other aromatic compounds found in mammalian digestive tracts or in soil as a carbon source. While most known flavin monooxygenases use NADH or NADPH as substrates (and use the flavins FAD or FMN as prosthetic groups ), this enzyme is part of a two-component system, in which a flavin oxidoreductase partner (EC 1.5.1.37) regenerates FADH2 by oxidizing NADH to NAD+. hpaB and hpaC, the 4-HPA oxygenase and reductase partner proteins (respectively) of E. coli strain W, were the first two-component flavin monoxygenase system identified. While known examples of this enzyme share a common catalytic mechanism and likely evolutionary origin, they differ with respect to regulation and ability to substitute FMNH2 for FADH2 as a substrate. (en)
- La 4-idrossifenilacetato 3-monoossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 4-idrossifenilacetato + NADH + H+ + O2 ⇄ 3,4-diidrossifenilacetato + NAD+ + H2O L'enzima è una flavoproteina. (it)
- 4-ヒドロキシフェニル酢酸-3-モノオキシゲナーゼ（4-hydroxyphenylacetate 3-monooxygenase）は、チロシン代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 4-ヒドロキシフェニル酢酸 + NADH + H+ + O2 3,4-ジヒドロキシフェニル酢酸 + NAD+ + H2O 反応式の通り、この酵素の基質は4-ヒドロキシフェニル酢酸とNADHとH+とO2、生成物は3,4-ジヒドロキシフェニル酢酸とNAD+とH2Oである。補酵素としてFADを用いる。 組織名は4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)で、別名にp-hydroxyphenylacetate 3-hydroxylase、4-hydroxyphenylacetic acid-3-hydroxylase、p-hydroxyphenylacetate hydroxylase、4 HPA 3-hydroxylase、p-hydroxyphenylacetate 3-hydroxylaseがある。 (ja)
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- PyMOL-generated cartoon of a Thermus thermophilus hpaB monomer complexed to FAD and 4-hydroxyphenylacetate. Color-coding distinguishes the enzyme's three primary structural domains. (en)
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- La 4-idrossifenilacetato 3-monoossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 4-idrossifenilacetato + NADH + H+ + O2 ⇄ 3,4-diidrossifenilacetato + NAD+ + H2O L'enzima è una flavoproteina. (it)
- 4-ヒドロキシフェニル酢酸-3-モノオキシゲナーゼ（4-hydroxyphenylacetate 3-monooxygenase）は、チロシン代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 4-ヒドロキシフェニル酢酸 + NADH + H+ + O2 3,4-ジヒドロキシフェニル酢酸 + NAD+ + H2O 反応式の通り、この酵素の基質は4-ヒドロキシフェニル酢酸とNADHとH+とO2、生成物は3,4-ジヒドロキシフェニル酢酸とNAD+とH2Oである。補酵素としてFADを用いる。 組織名は4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)で、別名にp-hydroxyphenylacetate 3-hydroxylase、4-hydroxyphenylacetic acid-3-hydroxylase、p-hydroxyphenylacetate hydroxylase、4 HPA 3-hydroxylase、p-hydroxyphenylacetate 3-hydroxylaseがある。 (ja)
- 4-hydroxyphenylacetate 3-monooxygenase (EC 1.14.14.9) is an enzyme that catalyzes the chemical reaction 4-hydroxyphenylacetate + FADH2 + O2 3,4-dihydroxyphenylacetate + FAD + H2O This reaction is the first step in a pathway found in enteric bacteria such as Escherichia coli and soil bacteria such as Pseudomonas putida which degrades 4-hydroxyphenylacetate (4-HPA), allowing these bacteria to use 4-HPA and other aromatic compounds found in mammalian digestive tracts or in soil as a carbon source. While most known flavin monooxygenases use NADH or NADPH as substrates (and use the flavins FAD or FMN as prosthetic groups ), this enzyme is part of a two-component system, in which a flavin oxidoreductase partner (EC 1.5.1.37) regenerates FADH2 by oxidizing NADH to NAD+. hpaB and hpaC, the 4-HPA (en)
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- 4-Hydroxyphenylacetate 3-monooxygenase (en)
- 4-idrossifenilacetato 3-monoossigenasi (it)
- 4-ヒドロキシフェニル酢酸-3-モノオキシゲナーゼ (ja)
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- 4-hydroxyphenylacetate 3-monooxygenase (en)
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