About: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

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In enzymology, a 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (HMB-PP synthase, IspG, EC 1.17.7.1) is an enzyme that catalyzes the chemical reaction 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide The substrate of this enzyme is 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) and the product is (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate (HMB-PP). Electrons are donated by two reduced ferredoxin proteins per reaction.

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  • In enzymology, a 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (HMB-PP synthase, IspG, EC 1.17.7.1) is an enzyme that catalyzes the chemical reaction 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide The substrate of this enzyme is 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) and the product is (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate (HMB-PP). Electrons are donated by two reduced ferredoxin proteins per reaction. This enzyme participates in the MEP pathway (non-mevalonate pathway) of Isoprenoid precursor biosynthesis. (en)
  • La (E)-4-hydroxy-3-méthylbut-2-ényle diphosphate synthase est une oxydoréductase qui catalyse la conversion du 2-C-méthyl-D-érythritol-2,4-cyclopyrophosphate (MEcPP) en (E)-4-hydroxy-3-méthyl-but-2-ényl-pyrophosphate (HMB-PP) : Cette enzyme intervient à la sixième étape de la voie du méthylérythritol phosphate, qui est une voie métabolique de biosynthèse de l'isopentényl-pyrophosphate (IPP) et du diméthylallyl-pyrophosphate (DMAPP) alternative à la voie du mévalonate chez les plantes, certains protozoaires et la plupart des bactéries, l'IPP et le DMAPP étant des métabolites qui conduisent notamment à la synthèse des terpénoïdes. Elle a été reclassifiée EC 1.17.7.1 par l'Enzyme Commission, son numéro initial ayant été EC 1.17.4.3. * Portail de la biochimie (fr)
  • La 4-idrossi-3-metilbut-2-en-1-ile difosfato sintasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: (E)-4-idrossi-3-metilbut-2-en-1-ile difosfato + H2O + proteina-disolfuro ⇄ 2-C-metil-D-eritritolo 2,4-ciclodifosfato + proteina-ditiolo Fa parte, nella direzione inversa a quella riportata, di una via alternativa di biosintesi dei terpenoidi (che non coinvolge il mevalonato). (it)
  • (E)-4-ヒドロキシ-3-メチル-2-ブテニル二リン酸シンターゼ((E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase)は、テルペノイド骨格生合成酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 (E)-4-ヒドロキシ-3-メチルブタ-2-エン-1-イル二リン酸 + H2O + 酸化型フェレドキシン 2-C-メチル-D-エリトリトール-2,4-シクロピロリン酸 + 還元型フェレドキシン この酵素の基質は(E)-4-ヒドロキシ-3-メチルブタ-2-エン-1-イル二リン酸、H2O と酸化型フェレドキシンで、生成物は2-C-メチル-D-エリトリトール-2,4-シクロピロリン酸と還元型フェレドキシンである。 この酵素は酸化還元酵素に属し、鉄硫黄タンパク質を受容体としてCH基またはCH2基に特異的に作用する。組織名は(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductaseで、別名に4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase、(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating) (incorrect)、(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase、GcpEがある。 (ja)
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  • 1.17.7.1
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  • La 4-idrossi-3-metilbut-2-en-1-ile difosfato sintasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: (E)-4-idrossi-3-metilbut-2-en-1-ile difosfato + H2O + proteina-disolfuro ⇄ 2-C-metil-D-eritritolo 2,4-ciclodifosfato + proteina-ditiolo Fa parte, nella direzione inversa a quella riportata, di una via alternativa di biosintesi dei terpenoidi (che non coinvolge il mevalonato). (it)
  • In enzymology, a 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (HMB-PP synthase, IspG, EC 1.17.7.1) is an enzyme that catalyzes the chemical reaction 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide The substrate of this enzyme is 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) and the product is (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate (HMB-PP). Electrons are donated by two reduced ferredoxin proteins per reaction. (en)
  • La (E)-4-hydroxy-3-méthylbut-2-ényle diphosphate synthase est une oxydoréductase qui catalyse la conversion du 2-C-méthyl-D-érythritol-2,4-cyclopyrophosphate (MEcPP) en (E)-4-hydroxy-3-méthyl-but-2-ényl-pyrophosphate (HMB-PP) : Elle a été reclassifiée EC 1.17.7.1 par l'Enzyme Commission, son numéro initial ayant été EC 1.17.4.3. * Portail de la biochimie (fr)
  • (E)-4-ヒドロキシ-3-メチル-2-ブテニル二リン酸シンターゼ((E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase)は、テルペノイド骨格生合成酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 (E)-4-ヒドロキシ-3-メチルブタ-2-エン-1-イル二リン酸 + H2O + 酸化型フェレドキシン 2-C-メチル-D-エリトリトール-2,4-シクロピロリン酸 + 還元型フェレドキシン この酵素の基質は(E)-4-ヒドロキシ-3-メチルブタ-2-エン-1-イル二リン酸、H2O と酸化型フェレドキシンで、生成物は2-C-メチル-D-エリトリトール-2,4-シクロピロリン酸と還元型フェレドキシンである。 (ja)
rdfs:label
  • 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (en)
  • 4-idrossi-3-metilbut-2-en-1-ile difosfato sintasi (it)
  • (E)-4-Hydroxy-3-méthylbut-2-ényle diphosphate synthase (fr)
  • (E)-4-ヒドロキシ-3-メチル-2-ブテニル二リン酸シンターゼ (ja)
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  • 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (en)
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