The 2022 FINA Marathon Swim World Series began on 28 May 2022 in Setúbal, Portugal for the first leg and ended in Eilat, Israel on 12 November 2022 for the fifth and final leg. It was the 16th edition of the FINA-sanctioned series. The 4×1500 metre mixed relay event was brought back after its debut at the final leg of the 2021 FINA Marathon Swim World Series and as part of the Abu Dhabi Aquatics Festival. Officials and athletes from Russia and Belarus were banned from the entirety of the World Series due to the 2022 Russia invasion of Ukraine.