The second 1959 Major League Baseball All-Star Game was the 27th edition of the midsummer classic between the all-stars of the American League (AL) and National League (NL), the two leagues composing Major League Baseball. It was played on Monday, August 3, at the Los Angeles Memorial Coliseum in Los Angeles, California, home of the Los Angeles Dodgers of the NL, and was a 5–3 victory for the American League. This was the second of two All-Star Games played in 1959, the first was on Tuesday, July 7, in Pittsburgh, Pennsylvania, also an NL city.