The 1915 South Carolina 4th congressional district special election was held on September 14, 1915, to select a Representative for the 4th congressional district to serve out the remainder of the term for the 64th Congress. The special election resulted from the resignation of Representative Joseph T. Johnson on April 19, 1915. Samuel J. Nicholls, a former state Representative from Spartanburg, won the Democratic primary and was unopposed in the general election.