Tebipenem (brand name: Orapenem) is a broad-spectrum orally-administered antibiotic, from the carbapenem subgroup of β-lactam antibiotics. It was developed as a replacement drug to combat bacteria that had acquired antibiotic resistance to commonly used antibiotics. Tebipenem is formulated as the ester tebipenem pivoxil due to the better absorption and improved bioavailability of this form. It has performed well in clinical trials for ear infection and looks likely to be further developed in future. It is only marketed in Japan. Tebipenem is the first carbapenem whose prodrug form, the pivalyl ester, is orally available.

Property Value
dbo:abstract
  • Tebipenempivoxil ist ein Arzneistoff, der zur Gruppe der Carbapeneme gehört und peroral wirksam ist. In Japan erhielt es im Februar 2009 die Zulassung zur Behandlung bestimmter Infektionskrankheiten bei Kindern. Tebipenempivoxil wird dort von der Firma Meiji Seika unter dem Namen Orapenem vertrieben. In Europa besteht keine Zulassung. (de)
  • Tebipenem (brand name: Orapenem) is a broad-spectrum orally-administered antibiotic, from the carbapenem subgroup of β-lactam antibiotics. It was developed as a replacement drug to combat bacteria that had acquired antibiotic resistance to commonly used antibiotics. Tebipenem is formulated as the ester tebipenem pivoxil due to the better absorption and improved bioavailability of this form. It has performed well in clinical trials for ear infection and looks likely to be further developed in future. It is only marketed in Japan. Tebipenem is the first carbapenem whose prodrug form, the pivalyl ester, is orally available. (en)
dbo:casNumber
  • 161715-24-8
dbo:iupacName
  • (4R,5S,6S)-(Pivaloyloxy)methyl 3-((1-(4,5-dihydrothiazol-2-yl)azetidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate (en)
dbo:thumbnail
dbo:wikiPageID
  • 40037895 (xsd:integer)
dbo:wikiPageRevisionID
  • 737437146 (xsd:integer)
dbp:c
  • 22 (xsd:integer)
dbp:caption
  • Tebipenem pivoxil
dbp:h
  • 31 (xsd:integer)
dbp:legalStatus
  • Prescription-only in Japan; investigational elsewhere
dbp:molecularWeight
  • 497.630000 (xsd:double)
dbp:n
  • 3 (xsd:integer)
dbp:o
  • 6 (xsd:integer)
dbp:pdbLigand
  • 1 (xsd:integer)
dbp:routesOfAdministration
  • Oral
dbp:s
  • 2 (xsd:integer)
dbp:smiles
  • [H][C@]12NC=O
dbp:tradename
  • Orapenem
dct:subject
http://purl.org/linguistics/gold/hypernym
rdf:type
rdfs:comment
  • Tebipenempivoxil ist ein Arzneistoff, der zur Gruppe der Carbapeneme gehört und peroral wirksam ist. In Japan erhielt es im Februar 2009 die Zulassung zur Behandlung bestimmter Infektionskrankheiten bei Kindern. Tebipenempivoxil wird dort von der Firma Meiji Seika unter dem Namen Orapenem vertrieben. In Europa besteht keine Zulassung. (de)
  • Tebipenem (brand name: Orapenem) is a broad-spectrum orally-administered antibiotic, from the carbapenem subgroup of β-lactam antibiotics. It was developed as a replacement drug to combat bacteria that had acquired antibiotic resistance to commonly used antibiotics. Tebipenem is formulated as the ester tebipenem pivoxil due to the better absorption and improved bioavailability of this form. It has performed well in clinical trials for ear infection and looks likely to be further developed in future. It is only marketed in Japan. Tebipenem is the first carbapenem whose prodrug form, the pivalyl ester, is orally available. (en)
rdfs:label
  • Tebipenempivoxil (de)
  • Tebipenem (en)
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