A synonymous substitution (also called a silent substitution) is the evolutionary substitution of one base for another in an exon of a gene coding for a protein, such that the amino acid sequence produced is not modified. Synonymous substitutions and mutations affecting noncoding DNA are collectively known as silent mutations.

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  • A synonymous substitution (also called a silent substitution) is the evolutionary substitution of one base for another in an exon of a gene coding for a protein, such that the amino acid sequence produced is not modified. Synonymous substitutions and mutations affecting noncoding DNA are collectively known as silent mutations.
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  • A synonymous substitution (also called a silent substitution) is the evolutionary substitution of one base for another in an exon of a gene coding for a protein, such that the amino acid sequence produced is not modified. Synonymous substitutions and mutations affecting noncoding DNA are collectively known as silent mutations.
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  • Synonymous substitution
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