Sulfatides are a class of sulfated galactosylceramides synthesized primarily in the oligodendrocytes in the central nervous system. Sulfatides are a type of sulfolipid. Sulfatides are thought to play a major role in myelin function and stability, as evidenced by the fact that mice lacking the enzyme necessary to produce sulfatides during myelin sheath formation have thinner myelin sheaths, and experience progressive hindlimb paralysis as a result of demyelination of their lower spinal cords.
| Property | Value |
|---|
| dbpedia-owl:abstract
|
- Sulfatide sind Hydrogensulfatester von Glycosphingolipiden. Es handelt sich um Cerebroside, bei denen am C3 des Glycosylrestes eine Sulfatgruppe angelagert ist. Der Donor ist 3′-Phosphoadenosin-5′-phosphosulfat (PAPS). Sie werden primär in Oligodendrozyten im ZNS gebildet. Ein Defekt oder Mangel der Sulfat-abspaltenden Sulfatidase Arylsulfatase A und die daraus resultierende Akkumulation von Sulfatiden in den Lysosomen von Oligodendrozyten führt zu metachromatischer Leukodystrophie.
- Sulfatides are a class of sulfated galactosylceramides synthesized primarily in the oligodendrocytes in the central nervous system. Sulfatides are a type of sulfolipid. Sulfatides are thought to play a major role in myelin function and stability, as evidenced by the fact that mice lacking the enzyme necessary to produce sulfatides during myelin sheath formation have thinner myelin sheaths, and experience progressive hindlimb paralysis as a result of demyelination of their lower spinal cords.
|
| dbpedia-owl:thumbnail
| |
| dbpprop:hasPhotoCollection
| |
| dcterms:subject
| |
| rdfs:comment
|
- Sulfatide sind Hydrogensulfatester von Glycosphingolipiden. Es handelt sich um Cerebroside, bei denen am C3 des Glycosylrestes eine Sulfatgruppe angelagert ist. Der Donor ist 3′-Phosphoadenosin-5′-phosphosulfat (PAPS). Sie werden primär in Oligodendrozyten im ZNS gebildet. Ein Defekt oder Mangel der Sulfat-abspaltenden Sulfatidase Arylsulfatase A und die daraus resultierende Akkumulation von Sulfatiden in den Lysosomen von Oligodendrozyten führt zu metachromatischer Leukodystrophie.
- Sulfatides are a class of sulfated galactosylceramides synthesized primarily in the oligodendrocytes in the central nervous system. Sulfatides are a type of sulfolipid. Sulfatides are thought to play a major role in myelin function and stability, as evidenced by the fact that mice lacking the enzyme necessary to produce sulfatides during myelin sheath formation have thinner myelin sheaths, and experience progressive hindlimb paralysis as a result of demyelination of their lower spinal cords.
|
| rdfs:label
| |
| owl:sameAs
| |
| http://www.w3.org/ns/prov#wasDerivedFrom
| |
| foaf:depiction
| |
| foaf:isPrimaryTopicOf
| |
| is dbpedia-owl:wikiPageRedirects
of | |
| is dbpprop:caption
of | |
| is foaf:primaryTopic
of | |
