Promegestone (INN) (brand name Surgestone), also known as 17α,21-dimethyl-Δ9-19-norprogesterone or 17α,21-dimethyl-19-norpregna-4,9-diene-3,20-dione, is a steroidal progestin of the 19-norprogesterone group which was introduced in 1983 and is marketed in France, Portugal, and Argentina. Indications include gynaecological conditions caused by luteal insufficiency, including premenopausal disorders, dysmenorrhea, and premenstrual syndrome. Promegestone has weak glucocorticoid activity, but does not bind to the androgen receptor or possess antimineralocorticoid activity. In addition, promegestone has been found to act as a non-competitive antagonist of the nicotinic acetylcholine receptor, similarly to progesterone. The drug is mainly bound to albumin; it does not bind to sex hormone-binding

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dbo:abstract
  • Promegestone (INN) (brand name Surgestone), also known as 17α,21-dimethyl-Δ9-19-norprogesterone or 17α,21-dimethyl-19-norpregna-4,9-diene-3,20-dione, is a steroidal progestin of the 19-norprogesterone group which was introduced in 1983 and is marketed in France, Portugal, and Argentina. Indications include gynaecological conditions caused by luteal insufficiency, including premenopausal disorders, dysmenorrhea, and premenstrual syndrome. Promegestone has weak glucocorticoid activity, but does not bind to the androgen receptor or possess antimineralocorticoid activity. In addition, promegestone has been found to act as a non-competitive antagonist of the nicotinic acetylcholine receptor, similarly to progesterone. The drug is mainly bound to albumin; it does not bind to sex hormone-binding globulin, and binds only weakly to transcortin. (en)
dbo:atcPrefix
  • G03
dbo:atcSuffix
  • DB07
dbo:casNumber
  • 34184-77-5
dbo:iupacName
  • (8S,13S,14S,17S)-13,17-Dimethyl-17-propionyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one (en)
dbo:pubchem
  • 36709
dbo:thumbnail
dbo:wikiPageID
  • 23484695 (xsd:integer)
dbo:wikiPageRevisionID
  • 742701468 (xsd:integer)
dbp:c
  • 22 (xsd:integer)
dbp:chemspiderid
  • 33716 (xsd:integer)
dbp:h
  • 30 (xsd:integer)
dbp:kegg
  • D08431
dbp:molecularWeight
  • 326.472000 (xsd:double)
dbp:o
  • 2 (xsd:integer)
dbp:smiles
  • CCC[C@]1C
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • QFFCYTLOTYIJMR-XMGTWHOFSA-N
dbp:synonyms
  • R-5020; RU-5020
dct:subject
http://purl.org/linguistics/gold/hypernym
rdf:type
rdfs:comment
  • Promegestone (INN) (brand name Surgestone), also known as 17α,21-dimethyl-Δ9-19-norprogesterone or 17α,21-dimethyl-19-norpregna-4,9-diene-3,20-dione, is a steroidal progestin of the 19-norprogesterone group which was introduced in 1983 and is marketed in France, Portugal, and Argentina. Indications include gynaecological conditions caused by luteal insufficiency, including premenopausal disorders, dysmenorrhea, and premenstrual syndrome. Promegestone has weak glucocorticoid activity, but does not bind to the androgen receptor or possess antimineralocorticoid activity. In addition, promegestone has been found to act as a non-competitive antagonist of the nicotinic acetylcholine receptor, similarly to progesterone. The drug is mainly bound to albumin; it does not bind to sex hormone-binding (en)
rdfs:label
  • Promegestone (en)
owl:sameAs
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