Proinflammatory cytokines are cytokines that are important in cell signaling and promote systemic inflammation. They are produced predominantly by activated macrophages and are involved in the upregulation of inflammatory reactions. In contrast to anti-inflammatory cytokines, which promote healing and reduce inflammation, proinflammatory cytokines act to make a disease worse. For patients with harmful excess inflammatory reactions, anticytokine therapies include neutralizing antibodies, serving as soluble receptors and receptor antagonists, and inhibiting proteases. Proinflammatory cytokines arise from genes that code for the translation of small mediator molecules that induce a response after upregulation. For example, chemokines are a class of genes that are proinflammatory. IL-1, TNF al

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  • السيتوكينات المنشطة للاتهابات (بالإنجليزية: Proinflammatory cytokine) هي نوع من السيتكون الخلوي الذي يحفز عملية حدوث التهاب والمسؤول عن بدء عملية الالتهابويسمى المحطى المناعية الرابعة للخلايا الملتهمة وتقسم هذه السيتوكينات الى نوعين وهم الإنترلوكين 1(Interleukin 1) وعامل نخر الورم ألفا (TNF alpha) . وعن طريق تشخيص نسبة افراز هذه السيتوكينات وكذلك نشاط الخلايا الملتهمة ,يمكن تقدير ما اذا رد فعل الجهاز المناعي طبيعي او زائد قد يؤدي الى امراض المناعة الزائدة أو الناقصة . (ar)
  • Cytokiny prozapalne – umowna nazwa dla grupy cytokin, od których zależy inicjacja reakcji zapalnej. Najważniejsze z nich to Interleukina 1, Interleukina 6 i TNF. Zapoznaj się z zastrzeżeniami dotyczącymi pojęć medycznych i pokrewnych w Wikipedii. (pl)
  • 促炎性细胞因子(英语:Proinflammatory cytokine)是一系列可以促进炎症的细胞因子的总称。 比较常见的促炎细胞因子包括白细胞介素-1(IL-1)和肿瘤坏死因子α(TNF alpha)。 (zh)
  • Proinflammatory cytokines are cytokines that are important in cell signaling and promote systemic inflammation. They are produced predominantly by activated macrophages and are involved in the upregulation of inflammatory reactions. In contrast to anti-inflammatory cytokines, which promote healing and reduce inflammation, proinflammatory cytokines act to make a disease worse. For patients with harmful excess inflammatory reactions, anticytokine therapies include neutralizing antibodies, serving as soluble receptors and receptor antagonists, and inhibiting proteases. Proinflammatory cytokines arise from genes that code for the translation of small mediator molecules that induce a response after upregulation. For example, chemokines are a class of genes that are proinflammatory. IL-1, TNF alpha, and chemokines are examples of proinflammatory cytokines. Proinflammatory cytokines work with other important molecules from the immune system, such as neutrophils and leukocytes, in generating an immune response. This proinflammatory cytokine-mediated inflammation generates a collection of gene products in response to a trigger of a foreign body. However, excessive amounts of proinflammatory cytokines have been shown to cause detrimental effects, such as chronic systemic elevations in the body. A lack of regulation in the release of these cytokines has been linked to different diseases, such as atherosclerosis and cancer. There are further implications that the misregulation of proinflammatory cytokines is also linked to depression and other neurologically related effects to the body[3]. It is important that the regulation between proinflammatory and anti-inflammatory cytokines stay balanced, as it could alter one's susceptibility to a disease. Aging and exercise also play a role in the amount of inflammation from the release of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-α). Recent therapies have looked into blocking proinflammatory cytokines in order to prevent the attack of these cytokines against our own bodies. (en)
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  • السيتوكينات المنشطة للاتهابات (بالإنجليزية: Proinflammatory cytokine) هي نوع من السيتكون الخلوي الذي يحفز عملية حدوث التهاب والمسؤول عن بدء عملية الالتهابويسمى المحطى المناعية الرابعة للخلايا الملتهمة وتقسم هذه السيتوكينات الى نوعين وهم الإنترلوكين 1(Interleukin 1) وعامل نخر الورم ألفا (TNF alpha) . وعن طريق تشخيص نسبة افراز هذه السيتوكينات وكذلك نشاط الخلايا الملتهمة ,يمكن تقدير ما اذا رد فعل الجهاز المناعي طبيعي او زائد قد يؤدي الى امراض المناعة الزائدة أو الناقصة . (ar)
  • Cytokiny prozapalne – umowna nazwa dla grupy cytokin, od których zależy inicjacja reakcji zapalnej. Najważniejsze z nich to Interleukina 1, Interleukina 6 i TNF. Zapoznaj się z zastrzeżeniami dotyczącymi pojęć medycznych i pokrewnych w Wikipedii. (pl)
  • 促炎性细胞因子(英语:Proinflammatory cytokine)是一系列可以促进炎症的细胞因子的总称。 比较常见的促炎细胞因子包括白细胞介素-1(IL-1)和肿瘤坏死因子α(TNF alpha)。 (zh)
  • Proinflammatory cytokines are cytokines that are important in cell signaling and promote systemic inflammation. They are produced predominantly by activated macrophages and are involved in the upregulation of inflammatory reactions. In contrast to anti-inflammatory cytokines, which promote healing and reduce inflammation, proinflammatory cytokines act to make a disease worse. For patients with harmful excess inflammatory reactions, anticytokine therapies include neutralizing antibodies, serving as soluble receptors and receptor antagonists, and inhibiting proteases. Proinflammatory cytokines arise from genes that code for the translation of small mediator molecules that induce a response after upregulation. For example, chemokines are a class of genes that are proinflammatory. IL-1, TNF al (en)
rdfs:label
  • سيتوكين منشط للالتهاب (ar)
  • Cytokiny prozapalne (pl)
  • 促炎性细胞因子 (zh)
  • Proinflammatory cytokine (en)
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