Polysaccharide-K is a protein-bound polysaccharide, which is used as an immune system boosting agent in the treatment of cancer in some countries in Europe as well as China and Japan. In Japan, PSK is approved as an adjuvant for cancer therapy and is covered by government health insurance. PSK is isolated from the mushroom Trametes versicolor. Preliminary evidence indicates PSK may have anticancer activity in vitro, in vivo and in human clinical trials.
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- クレスチン（Krestin）は、クレハ・第一三共より販売されている抗悪性腫瘍剤（生物学的応答調節剤）の商品名（登録商標）である。PSK (polysaccharide-Kureha) という略号で表されることもあるが、こちらも登録商標である。成分は、カワラタケ（Trametes versicolor）CM-101株菌糸体より得られる多糖類でタンパク質と結合している。 本剤は手間のかからない経口投与で、深刻な副作用がないことから、1977年の販売開始後、単独でかなり多く使われた時期があった。 しかし、現在では本剤単独では効果がないことが判明しており、他剤との併用で用いられる。 クレスチンは、担癌により低下した免疫応答機構に作用することにより抗腫瘍作用を発揮すると考えられる。
- Polysaccharide-K is a protein-bound polysaccharide, which is used as an immune system boosting agent in the treatment of cancer in some countries in Europe as well as China and Japan. In Japan, PSK is approved as an adjuvant for cancer therapy and is covered by government health insurance. PSK is isolated from the mushroom Trametes versicolor. Preliminary evidence indicates PSK may have anticancer activity in vitro, in vivo and in human clinical trials. Preliminary research has also demonstrated that PSK may inhibit various cancer onset mechanisms. Preliminary evidence indicates PSK may have use as an adjuvant in the treatment of gastric, esophageal, colorectal, breast and lung cancers. Human clinical trials suggest PSK may affect cancer recurrence when used as an adjuvant, and basic research has demonstrated it inhibited certain human cancer cell lines in vitro. The MD Anderson Cancer Center reported that it is a "promising candidate for chemoprevention due to the multiple effects on the malignant process, limited side effects and safety of daily oral doses for extended periods of time. " In fact, the Therapeutic Goods Administration in Australia reported that the WHO has only eight records of adverse effects with PSK and none reported for PSP.
- Polissacarídeo-K (PSK) é um polissacarídeo ligado a uma proteína, usado como agente estimulante do sistema imunitário no tratamento do cancro em vários países da Europa, bem como na China e Japão. No Japão, o PSK está aprovado como adjuvante na terapia do cancro e é coberto pelo seguro de saúde estatal. O PSK é obtido do cogumelo Trametes versicolor. O PSK possui actividade anticancerígena documentada in vitro, in vivo e em ensaios clínicos em humanos. As pesquisas demonstraram também que o PSK pode reduzir o desenvolvimento de cancro espontâneo, e induzido por mutagenos ou radiação. Mostrou-se benéfico como adjuvante no tratamento de cancros do estômago, esófago, colorrectal, mama e pulmão. Os ensaios clínicos em humanos sugerem que o polissacarídeo-K pode reduzir a recorrência do cancro quando usado como adjuvante e as pesquisas demonstraram que o cogumelo pode inibir certas linhagens de células cancerígenas humanas in vitro.
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- クレスチン（Krestin）は、クレハ・第一三共より販売されている抗悪性腫瘍剤（生物学的応答調節剤）の商品名（登録商標）である。PSK (polysaccharide-Kureha) という略号で表されることもあるが、こちらも登録商標である。成分は、カワラタケ（Trametes versicolor）CM-101株菌糸体より得られる多糖類でタンパク質と結合している。 本剤は手間のかからない経口投与で、深刻な副作用がないことから、1977年の販売開始後、単独でかなり多く使われた時期があった。 しかし、現在では本剤単独では効果がないことが判明しており、他剤との併用で用いられる。 クレスチンは、担癌により低下した免疫応答機構に作用することにより抗腫瘍作用を発揮すると考えられる。
- Polissacarídeo-K (PSK) é um polissacarídeo ligado a uma proteína, usado como agente estimulante do sistema imunitário no tratamento do cancro em vários países da Europa, bem como na China e Japão. No Japão, o PSK está aprovado como adjuvante na terapia do cancro e é coberto pelo seguro de saúde estatal. O PSK é obtido do cogumelo Trametes versicolor. O PSK possui actividade anticancerígena documentada in vitro, in vivo e em ensaios clínicos em humanos.
- Polysaccharide-K is a protein-bound polysaccharide, which is used as an immune system boosting agent in the treatment of cancer in some countries in Europe as well as China and Japan. In Japan, PSK is approved as an adjuvant for cancer therapy and is covered by government health insurance. PSK is isolated from the mushroom Trametes versicolor. Preliminary evidence indicates PSK may have anticancer activity in vitro, in vivo and in human clinical trials.
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- クレスチン
- Polissacarídeo-K
- Polysaccharide-K
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