Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxin B is composed of a number of related compounds (see ""). It has a bactericidal action against almost all Gram-negative bacilli except the Proteus and Neisseria genera. Polymyxins bind to the cell membrane and alter its structure, making it more permeable. The resulting water uptake leads to cell death. Polymyxins are cationic, basic peptides that act like detergents (surfactants). Side effects include neurotoxicity and acute renal tubular necrosis. Polymyxins are used in the topical first-aid preparation Neosporin.

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dbo:abstract
  • Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxin B is composed of a number of related compounds (see ""). It has a bactericidal action against almost all Gram-negative bacilli except the Proteus and Neisseria genera. Polymyxins bind to the cell membrane and alter its structure, making it more permeable. The resulting water uptake leads to cell death. Polymyxins are cationic, basic peptides that act like detergents (surfactants). Side effects include neurotoxicity and acute renal tubular necrosis. Polymyxins are used in the topical first-aid preparation Neosporin. 1. * Family of polypeptides with attached fatty acid; cationic detergent at physiological pH, both hydrophilic and hydrophobic properties 2. * Bactericidal for gram-negative; little to no effect on gram-positive, since cell wall is too thick to permit access to membrane (en)
  • La polimixina B è un agente tensioattivo costituito da una miscela di solfati di polipeptidi prodotti dalla coltura di alcuni ceppi di Bacillus polymyxa. Il prodotto disponibile in commercio è una miscela di polimixina B1 e di polimixina B2, le quali differiscono per la composizione del gruppo N-acilico. Infatti, per idrolisi acida, la polimixina B1 dà luogo alla formazione di acido (+)-6-metilottanoico, mentre la polimixina B2 dà origine a una molecola di acido 6-metileptanoico. Polimixina B pura nella quantità di 100 mg è equivalente a 1.000.000 UI. (it)
  • Polimyksyna B – antybiotyk z grupy polimyksyn, mieszanina peptydów wytwarzanych podczas wzrostu przez Bacillus polymyxa o strukturze łańcuchowo-pierścieniowej. (pl)
  • 多粘菌素B(英语:Polymyxin B,又名多黏菌素B)是一种主要用于治疗 革兰氏阴性菌感染药物。它是从一种名为Bacillus polymyxa的细菌中被分离出来的。多粘菌素B是多粘菌素的一种,由两种非常近似的化合物混合而成:多粘菌素B1和多粘菌素B2。除变形杆菌属外,它对几乎所有革兰氏阴性杆菌均有杀菌作用。多粘菌素的作用原理是与细胞膜粘附,改变细胞膜的结构使之通透性变强,细胞因吸收周围环境过多的水分而膨胀死亡。它是带有正电荷的碱性蛋白,像常用于去污的表面活性剂一样。副作用包括神经毒性以及急性肾小管坏死。 1. * 多粘菌素通常与脂肪酸结合,在生理条件下具有表面活性剂作用,具有亲水和疏水的双重特性 2. * 多粘菌素只用于革兰氏阴性菌感染的治疗,对革兰氏阳性菌几乎没有抗菌活性,因为革兰氏阳性菌的细胞壁太厚无法与细胞膜结合 (zh)
dbo:atcPrefix
  • A07
dbo:atcSuffix
  • AA05
dbo:casNumber
  • 1405-20-5
dbo:drugbank
  • DB00781
dbo:iupacName
  • N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide (en)
dbo:pubchem
  • 5702105
dbo:thumbnail
dbo:wikiPageID
  • 5155469 (xsd:integer)
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  • 737631411 (xsd:integer)
dbp:c
  • 56 (xsd:integer)
dbp:chembl
  • 1201283 (xsd:integer)
dbp:h
  • 100 (xsd:integer)
dbp:image
  • polymyxin B2.svg
dbp:legalStatus
  • OTC
dbp:molecularWeight
  • 1301.560000 (xsd:double)
dbp:n
  • 16 (xsd:integer)
dbp:niaidChemdb
  • 7797 (xsd:integer)
dbp:o
  • 17 (xsd:integer)
dbp:pregnancyCategory
  • C
dbp:routesOfAdministration
  • Topical, Intramuscular, Intravenous, Intrathecal, or Ophthalmic
dbp:s
  • 1 (xsd:integer)
dbp:verifiedfields
  • changed
dbp:verifiedrevid
  • 414279035 (xsd:integer)
dbp:watchedfields
  • changed
dct:subject
http://purl.org/linguistics/gold/hypernym
rdf:type
rdfs:comment
  • La polimixina B è un agente tensioattivo costituito da una miscela di solfati di polipeptidi prodotti dalla coltura di alcuni ceppi di Bacillus polymyxa. Il prodotto disponibile in commercio è una miscela di polimixina B1 e di polimixina B2, le quali differiscono per la composizione del gruppo N-acilico. Infatti, per idrolisi acida, la polimixina B1 dà luogo alla formazione di acido (+)-6-metilottanoico, mentre la polimixina B2 dà origine a una molecola di acido 6-metileptanoico. Polimixina B pura nella quantità di 100 mg è equivalente a 1.000.000 UI. (it)
  • Polimyksyna B – antybiotyk z grupy polimyksyn, mieszanina peptydów wytwarzanych podczas wzrostu przez Bacillus polymyxa o strukturze łańcuchowo-pierścieniowej. (pl)
  • 多粘菌素B(英语:Polymyxin B,又名多黏菌素B)是一种主要用于治疗 革兰氏阴性菌感染药物。它是从一种名为Bacillus polymyxa的细菌中被分离出来的。多粘菌素B是多粘菌素的一种,由两种非常近似的化合物混合而成:多粘菌素B1和多粘菌素B2。除变形杆菌属外,它对几乎所有革兰氏阴性杆菌均有杀菌作用。多粘菌素的作用原理是与细胞膜粘附,改变细胞膜的结构使之通透性变强,细胞因吸收周围环境过多的水分而膨胀死亡。它是带有正电荷的碱性蛋白,像常用于去污的表面活性剂一样。副作用包括神经毒性以及急性肾小管坏死。 1. * 多粘菌素通常与脂肪酸结合,在生理条件下具有表面活性剂作用,具有亲水和疏水的双重特性 2. * 多粘菌素只用于革兰氏阴性菌感染的治疗,对革兰氏阳性菌几乎没有抗菌活性,因为革兰氏阳性菌的细胞壁太厚无法与细胞膜结合 (zh)
  • Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxin B is composed of a number of related compounds (see ""). It has a bactericidal action against almost all Gram-negative bacilli except the Proteus and Neisseria genera. Polymyxins bind to the cell membrane and alter its structure, making it more permeable. The resulting water uptake leads to cell death. Polymyxins are cationic, basic peptides that act like detergents (surfactants). Side effects include neurotoxicity and acute renal tubular necrosis. Polymyxins are used in the topical first-aid preparation Neosporin. (en)
rdfs:label
  • Polymyxin B (en)
  • Polimixina B (it)
  • Polimyksyna B (pl)
  • 多粘菌素B (zh)
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