Nordihydroguaiaretic acid (NDGA) is an antioxidant compound found in the creosote bush (Larrea tridentata). The creosote plant has been used in herbal medicine, but its use is controversial. It was widely used during the 1950s as a food preservative and to preserve natural fibers, but was later banned after reports of toxicity during the early 1960s. Recently, it has been used as a nutritional supplement; however, renal toxicity and hepatotoxicity are reported for chronic use of creosote bush and NDGA.

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  • Nordihydroguaiaretic acid (NDGA) is an antioxidant compound found in the creosote bush (Larrea tridentata). The creosote plant has been used in herbal medicine, but its use is controversial. It was widely used during the 1950s as a food preservative and to preserve natural fibers, but was later banned after reports of toxicity during the early 1960s. Recently, it has been used as a nutritional supplement; however, renal toxicity and hepatotoxicity are reported for chronic use of creosote bush and NDGA. A 1986 study involved feeding female mosquitos NDGA to test the effect on their average life span. While the usual mosquito life span was 29 days, the NDGA-fed mosquitos lived an average of 45 days—an increase of 50 percent. A 2008 study reported that nordihydroguaiaretic acid lengthened the lifespan of male mice, but not of female mice. (en)
  • El ácido nordihidroguaiarético (ANDG) es un compuesto antioxidante que se encuentra en el arbusto de la creosota (Larrea tridentata). La planta ha sido usada como hierba medicinal pero su uso es controvertido. Fue ampliamente usada durante los años 50 como como conservante de alimentos y para preservar las fibras naturales, pero fue prohibido más tarde después de informes de toxicidad durante principios de los 60. Recientemente, ha sido usado como nutriente suplementario, sin embargo se han reportado toxicidad renal y hepatotoxicidad durante el uso crónico del arbusto de creosota y ANDG. (es)
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  • 4,4'-(2,3-Dimethylbutane-1,4-diyl)dibenzene-1,2-diol (en)
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  • NDGA.png
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http://purl.org/linguistics/gold/hypernym
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  • El ácido nordihidroguaiarético (ANDG) es un compuesto antioxidante que se encuentra en el arbusto de la creosota (Larrea tridentata). La planta ha sido usada como hierba medicinal pero su uso es controvertido. Fue ampliamente usada durante los años 50 como como conservante de alimentos y para preservar las fibras naturales, pero fue prohibido más tarde después de informes de toxicidad durante principios de los 60. Recientemente, ha sido usado como nutriente suplementario, sin embargo se han reportado toxicidad renal y hepatotoxicidad durante el uso crónico del arbusto de creosota y ANDG. (es)
  • Nordihydroguaiaretic acid (NDGA) is an antioxidant compound found in the creosote bush (Larrea tridentata). The creosote plant has been used in herbal medicine, but its use is controversial. It was widely used during the 1950s as a food preservative and to preserve natural fibers, but was later banned after reports of toxicity during the early 1960s. Recently, it has been used as a nutritional supplement; however, renal toxicity and hepatotoxicity are reported for chronic use of creosote bush and NDGA. (en)
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  • Nordihydroguaiaretic acid (en)
  • Ácido nordihidroguaiarético (es)
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