Nomegestrol acetate (NOMAC) (INN, USAN, USAN) (brand names Lutenyl (alone) and Naemis, Zoely (with estradiol)), or 19-normegestrol acetate, also known as 17α-acetoxy-6-dehydro-6-methyl-19-norprogesterone or 17α-acetoxy-6-methyl-19-norpregna-4,6-diene-3,20-dione, is an steroidal progestin of the 19-norprogesterone and 17α-hydroxyprogesterone groups which was first introduced in the 1980s and is used orally in the treatment of gynecological disorders and menopausal symptoms and as a hormonal contraceptive. It is widely available in Europe and in many other countries throughout the world, though notably not in the United States. NOMAC is the 17α-acetylated derivative of nomegestrol and the 19-demethylated (or 19-nor) analogue of megestrol acetate.

Property Value
dbo:abstract
  • Nomegestrol acetate (NOMAC) (INN, USAN, USAN) (brand names Lutenyl (alone) and Naemis, Zoely (with estradiol)), or 19-normegestrol acetate, also known as 17α-acetoxy-6-dehydro-6-methyl-19-norprogesterone or 17α-acetoxy-6-methyl-19-norpregna-4,6-diene-3,20-dione, is an steroidal progestin of the 19-norprogesterone and 17α-hydroxyprogesterone groups which was first introduced in the 1980s and is used orally in the treatment of gynecological disorders and menopausal symptoms and as a hormonal contraceptive. It is widely available in Europe and in many other countries throughout the world, though notably not in the United States. NOMAC is the 17α-acetylated derivative of nomegestrol and the 19-demethylated (or 19-nor) analogue of megestrol acetate. (en)
dbo:atcPrefix
  • G03
dbo:atcSuffix
  • DB04
dbo:bioavailability
  • 63.000000 (xsd:float)
dbo:casNumber
  • 58652-20-3
dbo:fdaUniiCode
  • 83J78V5W05
dbo:iupacName
  • [(8S,9S,10R,13S,14S,17R)-17-acetyl-6,13-dimethyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate (en)
dbo:pubchem
  • 91668
dbo:thumbnail
dbo:wikiPageID
  • 26791100 (xsd:integer)
dbo:wikiPageRevisionID
  • 744900044 (xsd:integer)
dbp:c
  • 23 (xsd:integer)
dbp:chemspiderid
  • 82771 (xsd:integer)
dbp:eliminationHalfLife
  • 180000.0
dbp:excretion
dbp:h
  • 30 (xsd:integer)
dbp:kegg
  • D08281
dbp:legalStatus
  • Rx-only
dbp:metabolism
  • Hepatic
dbp:metabolites
  • Six main metabolites, all essentially inactive
dbp:molecularWeight
  • 370.481900 (xsd:double)
dbp:o
  • 4 (xsd:integer)
dbp:proteinBound
  • 97.500000 (xsd:double)
dbp:routesOfAdministration
dbp:smiles
  • CC1=CC2CC4C1=CCCC4
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • IIVBFTNIGYRNQY-YQLZSBIMSA-N
dbp:synonyms
  • NOMAC; NOMAc; TX-066; Uniplant; 19-Normegestrol acetate; 6-Methyl-17α-acetoxy-6-19-norprogesterone
dbp:tradename
  • Alone: Lutenyl
  • With : Naemis, Zoely
dbp:width
  • 275 (xsd:integer)
dct:subject
http://purl.org/linguistics/gold/hypernym
rdf:type
rdfs:comment
  • Nomegestrol acetate (NOMAC) (INN, USAN, USAN) (brand names Lutenyl (alone) and Naemis, Zoely (with estradiol)), or 19-normegestrol acetate, also known as 17α-acetoxy-6-dehydro-6-methyl-19-norprogesterone or 17α-acetoxy-6-methyl-19-norpregna-4,6-diene-3,20-dione, is an steroidal progestin of the 19-norprogesterone and 17α-hydroxyprogesterone groups which was first introduced in the 1980s and is used orally in the treatment of gynecological disorders and menopausal symptoms and as a hormonal contraceptive. It is widely available in Europe and in many other countries throughout the world, though notably not in the United States. NOMAC is the 17α-acetylated derivative of nomegestrol and the 19-demethylated (or 19-nor) analogue of megestrol acetate. (en)
rdfs:label
  • Nomegestrol acetate (en)
owl:sameAs
prov:wasDerivedFrom
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