NPS-2143 (SB-262,470A) is a calcilytic drug which acts as an antagonist at the Calcium-sensing receptor (CaSR), and consequently stimulates release of parathyroid hormone. Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents.

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dbo:abstract
  • NPS-2143 (SB-262,470A) is a calcilytic drug which acts as an antagonist at the Calcium-sensing receptor (CaSR), and consequently stimulates release of parathyroid hormone. Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents. (en)
dbo:casNumber
  • 324523-20-8
dbo:iupacName
  • 2-chloro-6-[(2R)-3-([1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino)-2-hydroxypropoxy]benzonitrile (en)
dbo:pubchem
  • 6918446
dbo:thumbnail
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  • 713222225 (xsd:integer)
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  • 24 (xsd:integer)
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  • 5293643 (xsd:integer)
dbp:cl
  • 1 (xsd:integer)
dbp:h
  • 25 (xsd:integer)
dbp:iupharLigand
  • 716 (xsd:integer)
dbp:molecularWeight
  • 408.919000 (xsd:double)
dbp:n
  • 2 (xsd:integer)
dbp:o
  • 2 (xsd:integer)
dbp:smiles
  • N#Cc2ccccc2OCCCNCCc3ccc1ccccc1c3
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  • 1 (xsd:integer)
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  • PZUJQWHTIRWCID-HXUWFJFHSA-N
dct:subject
http://purl.org/linguistics/gold/hypernym
rdf:type
rdfs:comment
  • NPS-2143 (SB-262,470A) is a calcilytic drug which acts as an antagonist at the Calcium-sensing receptor (CaSR), and consequently stimulates release of parathyroid hormone. Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents. (en)
rdfs:label
  • NPS-2143 (en)
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