Mexazolam (marketed under the trade names Melex and Sedoxil) is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up, however, after three weeks of therapy mexazolam had lost its therapeutic anxiolytic properties becoming no more effective than placebo, presumably due to benzodiazepine tolerance. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit the metabolism of mexazolam, but not the HMG-CoA reductase inhibitor pravastatin.

Property Value
dbo:abstract
  • メキサゾラム (mexazolam) はベンゾジアゼピン系の抗不安薬の一種。長時間作用型。 心身症からくる不安・緊張・抑うつ・睡眠障害および、パニック障害、自律神経失調症などに適応がある。日本での商品名はメレックス (ja)
  • Mexazolam é uma substância utilizada como medicamento pertencente ao grupo e sub-grupos: * Medicamentos Sistema nervoso central * Psicofármacos * Ansiolíticos, sedativos e hipnóticos * Benzodiazepinas (pt)
  • Mexazolam (marketed under the trade names Melex and Sedoxil) is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up, however, after three weeks of therapy mexazolam had lost its therapeutic anxiolytic properties becoming no more effective than placebo, presumably due to benzodiazepine tolerance. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit the metabolism of mexazolam, but not the HMG-CoA reductase inhibitor pravastatin. (en)
dbo:atcPrefix
  • none
dbo:casNumber
  • 31868-18-5
dbo:fdaUniiCode
  • S5969B6237
dbo:iupacName
  • 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one (en)
dbo:pubchem
  • 4177
dbo:thumbnail
dbo:wikiPageID
  • 9692425 (xsd:integer)
dbo:wikiPageRevisionID
  • 726839020 (xsd:integer)
dbp:c
  • 18 (xsd:integer)
dbp:chemspiderid
  • 4033 (xsd:integer)
dbp:cl
  • 2 (xsd:integer)
dbp:excretion
dbp:h
  • 16 (xsd:integer)
dbp:image
  • Mexazolam3d.png
dbp:kegg
  • D01316
dbp:legalCa
  • Schedule IV
dbp:legalUs
  • unscheduled
dbp:metabolism
  • Hepatic
dbp:molecularWeight
  • 363.237000 (xsd:double)
dbp:n
  • 2 (xsd:integer)
dbp:o
  • 2 (xsd:integer)
dbp:routesOfAdministration
  • Oral
dbp:smiles
  • Clc1ccccc1C42OCCC
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • ANUCDXCTICZJRH-UHFFFAOYSA-N
dbp:synonyms
  • (13-chloro- 2-- 5-methyl- 3-oxa- 6,9-diazatricyclo[8.4.0.02,6] tetradeca- 1,11,13-trien- 8-one)
dbp:tradename
  • Melex, Sedoxil
dbp:verifiedrevid
  • 451165363 (xsd:integer)
dbp:width
  • 155 (xsd:integer)
dct:subject
http://purl.org/linguistics/gold/hypernym
rdf:type
rdfs:comment
  • メキサゾラム (mexazolam) はベンゾジアゼピン系の抗不安薬の一種。長時間作用型。 心身症からくる不安・緊張・抑うつ・睡眠障害および、パニック障害、自律神経失調症などに適応がある。日本での商品名はメレックス (ja)
  • Mexazolam é uma substância utilizada como medicamento pertencente ao grupo e sub-grupos: * Medicamentos Sistema nervoso central * Psicofármacos * Ansiolíticos, sedativos e hipnóticos * Benzodiazepinas (pt)
  • Mexazolam (marketed under the trade names Melex and Sedoxil) is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up, however, after three weeks of therapy mexazolam had lost its therapeutic anxiolytic properties becoming no more effective than placebo, presumably due to benzodiazepine tolerance. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit the metabolism of mexazolam, but not the HMG-CoA reductase inhibitor pravastatin. (en)
rdfs:label
  • Mexazolam (en)
  • メキサゾラム (ja)
  • Mexazolam (pt)
owl:sameAs
prov:wasDerivedFrom
foaf:depiction
foaf:isPrimaryTopicOf
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