Mexazolam (marketed under the trade names Melex and Sedoxil) is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up, however, after three weeks of therapy mexazolam had lost its therapeutic anxiolytic properties becoming no more effective than placebo, presumably due to benzodiazepine tolerance. Mexazolam is metabolised via the CYP3A4 pathway.

Property Value
dbo:abstract
  • メキサゾラム (mexazolam) はベンゾジアゼピン系の抗不安薬の一種。長時間作用型。心身症からくる不安・緊張・抑うつ・睡眠障害および、パニック障害、自律神経失調症などに適応がある。日本での商品名はメレックス (ja)
  • Mexazolam é uma substância utilizada como medicamento pertencente ao grupo e sub-grupos:Medicamentos Sistema nervoso centralPsicofármacosAnsiolíticos, sedativos e hipnóticosBenzodiazepinas (pt)
  • Mexazolam (marketed under the trade names Melex and Sedoxil) is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up, however, after three weeks of therapy mexazolam had lost its therapeutic anxiolytic properties becoming no more effective than placebo, presumably due to benzodiazepine tolerance. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit the metabolism of mexazolam, but not the HMG-CoA reductase inhibitor pravastatin. (en)
dbo:atcPrefix
  • none
dbo:casNumber
  • 31868-18-5
dbo:fdaUniiCode
  • S5969B6237
dbo:iupacName
  • 10-chloro- 11b-(2-chlorophenyl)- 3-methyl- 2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin- 6(5H)-one (en)
dbo:pubchem
  • 4177
dbo:thumbnail
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  • 681763105 (xsd:integer)
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  • none (en)
dbp:bioavailability
  • ? (en)
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  • 18 (xsd:integer)
dbp:casNumber
  • 31868 (xsd:integer)
dbp:chemspiderid
  • 4033 (xsd:integer)
dbp:cl
  • 2 (xsd:integer)
dbp:eliminationHalfLife
  • ? (en)
dbp:excretion
dbp:h
  • 16 (xsd:integer)
dbp:image
  • Mexazolam3d.png (en)
dbp:inchi
  • 1 (xsd:integer)
dbp:inchikey
  • ANUCDXCTICZJRH-UHFFFAOYAN (en)
dbp:iupacName
  • 10 (xsd:integer)
dbp:kegg
  • D01316 (en)
dbp:legalStatus
dbp:metabolism
dbp:molecularWeight
  • 363.237000 (xsd:double)
dbp:n
  • 2 (xsd:integer)
dbp:o
  • 2 (xsd:integer)
dbp:pregnancyCategory
  • ? (en)
dbp:pubchem
  • 4177 (xsd:integer)
dbp:routesOfAdministration
  • Oral (en)
dbp:smiles
  • Clc1ccccc1C42OCCC (en)
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • ANUCDXCTICZJRH-UHFFFAOYSA-N (en)
dbp:synonyms
  • (13-chloro- 2-- 5-methyl- 3-oxa- 6,9-diazatricyclo[8.4.0.02,6] tetradeca- 1,11,13-trien- 8-one) (en)
dbp:unii
  • S5969B6237 (en)
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  • 150 (xsd:integer)
dct:subject
rdf:type
rdfs:comment
  • メキサゾラム (mexazolam) はベンゾジアゼピン系の抗不安薬の一種。長時間作用型。心身症からくる不安・緊張・抑うつ・睡眠障害および、パニック障害、自律神経失調症などに適応がある。日本での商品名はメレックス (ja)
  • Mexazolam é uma substância utilizada como medicamento pertencente ao grupo e sub-grupos:Medicamentos Sistema nervoso centralPsicofármacosAnsiolíticos, sedativos e hipnóticosBenzodiazepinas (pt)
  • Mexazolam (marketed under the trade names Melex and Sedoxil) is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up, however, after three weeks of therapy mexazolam had lost its therapeutic anxiolytic properties becoming no more effective than placebo, presumably due to benzodiazepine tolerance. Mexazolam is metabolised via the CYP3A4 pathway. (en)
rdfs:label
  • Mexazolam (en)
  • メキサゾラム (ja)
  • Mexazolam (pt)
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