Metabotropic glutamate receptor 5 is a protein that in humans is encoded by the GRM5 gene. The amino acid L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.
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- Metabotropic glutamate receptor 5 is a protein that in humans is encoded by the GRM5 gene. The amino acid L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7, and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.
- O Receptor metabotrópico de glutamato 5 é uma proteína que em seres humanos é codificada pelo gene GRM5. Os receptores metabotrópicos de glutamato são uma família de receptores acoplados à proteína G. Predefinição:Referências
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- O Receptor metabotrópico de glutamato 5 é uma proteína que em seres humanos é codificada pelo gene GRM5. Os receptores metabotrópicos de glutamato são uma família de receptores acoplados à proteína G. Predefinição:Referências
- Metabotropic glutamate receptor 5 is a protein that in humans is encoded by the GRM5 gene. The amino acid L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.
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- Receptor metabotrópico de glutamato 5
- Metabotropic glutamate receptor 5
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