Methyl-CpG binding domain protein 1, also known as MBD1, is a human gene. The protein encoded by MBD1 binds to methylated sequences in DNA, and thereby influences transcription. It binds to a variety of methylated sequences, and appears to mediate repression of gene expression. It has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. H3K9meis a repressive modification.

PropertyValue
dbpprop:abstract
  • Methyl-CpG binding domain protein 1, also known as MBD1, is a human gene. The protein encoded by MBD1 binds to methylated sequences in DNA, and thereby influences transcription. It binds to a variety of methylated sequences, and appears to mediate repression of gene expression. It has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. H3K9meis a repressive modification.
dbpprop:hasPhotoCollection
dbpprop:requireManualInspection
  • no
dbpprop:summaryText
  • DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21.
dbpprop:updateCitations
  • yes
dbpprop:updatePage
  • yes
dbpprop:updateProteinBox
  • yes
dbpprop:updateSummary
  • yes
dbpprop:wikiPageUsesTemplate
rdfs:comment
  • Methyl-CpG binding domain protein 1, also known as MBD1, is a human gene. The protein encoded by MBD1 binds to methylated sequences in DNA, and thereby influences transcription. It binds to a variety of methylated sequences, and appears to mediate repression of gene expression. It has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. H3K9meis a repressive modification.
rdfs:label
  • MBD1
owl:sameAs
skos:subject
foaf:page
is dbpprop:redirect of