Levonorgestrel implants, sold under the brandnames Norplant among others, is a type of contraceptive implant for birth control. It was developed by Sheldon J. Segal and Horatio B. Croxatto at the Population Council beginning in 1966, with the first clinical trial in Chile in 1974. It was first approved in Finland on November 23, 1983, where it was manufactured by Leiras Oy Pharmaceuticals. The original Norplant consisted of a set of six small (2.4 mm × 34 mm) silicone capsules, each filled with 36 mg of levonorgestrel (a progestin used in many birth control pills) implanted subdermally in the upper arm and effective for five years. The original (six capsule) Norplant's production has been phased out; USAID's contract ran until December 2006.The original (six capsule) Norplant was approved

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dbo:abstract
  • Levonorgestrel implants, sold under the brandnames Norplant among others, is a type of contraceptive implant for birth control. It was developed by Sheldon J. Segal and Horatio B. Croxatto at the Population Council beginning in 1966, with the first clinical trial in Chile in 1974. It was first approved in Finland on November 23, 1983, where it was manufactured by Leiras Oy Pharmaceuticals. The original Norplant consisted of a set of six small (2.4 mm × 34 mm) silicone capsules, each filled with 36 mg of levonorgestrel (a progestin used in many birth control pills) implanted subdermally in the upper arm and effective for five years. The original (six capsule) Norplant's production has been phased out; USAID's contract ran until December 2006.The original (six capsule) Norplant was approved by the U.S. Food and Drug Administration (FDA) on December 10, 1990, and marketed in the United States in 1991 by Wyeth Pharmaceuticals. Norplant distribution in the United States ended in 2002; limited supplies still remained in the U.S. until 2004. Norplant was withdrawn from the UK market in 1999. Production of Norplant was discontinued globally in 2008. Norplant II (Norplant-2, Jadelle), also developed by the Population Council and manufactured by Schering Oy, consists of two small (2.5 mm × 43 mm) silicone rods each containing 75 mg of levonorgestrel in a polymer matrix, instead of six capsules. It was approved May 31, 1996 by the FDA as being effective for three years; it was subsequently approved November 22, 2002 by the FDA as being effective for five years. Jadelle has not been marketed in the United States; Jadelle is the successor to the original Norplant in USAID's contract beginning January 2007. (en)
  • Norplant es la antigua marca de un implante subcutáneo usado como método anticonceptivo desarrollado en 1983 en Finlandia. 'Jadelle (Norplant II) es el nombre de la marca del implante de segunda generación aprobado en 1996. (es)
  • Norplant é uma forma de contraceptivo composto por seis pequenas cápsulas de silicone que são implantadas sob a pele do braço, sendo eficientes durante cinco anos. O Norplant II (Jadelle) consiste de dois pequenos bastões de silicone que são também implantados no braço. Implante impede a ovulação e quando ele não consegue impedir-la e ocorre a fecundação, forma-se o zigoto, implante impede a sua nidação através de alterações causadas à espessura do endométrio. (pt)
dbo:wikiPageID
  • 770854 (xsd:integer)
dbo:wikiPageRevisionID
  • 737592022 (xsd:integer)
dbp:bcType
  • Hormonal
  • Progestogen implant
dbp:benefits
  • No further user contraceptive action needed
dbp:clinicInterval
  • 7889400.0
dbp:dateFirstUse
  • 1983 (xsd:integer)
dbp:durationEffect
  • 1.57788E8
dbp:medicalNotes
  • Possible scarring and difficulty in removal
dbp:name
  • Levonorgestrel implant
dbp:perfectFailure%_
  • 0.050000 (xsd:double)
dbp:periodsDisadvantage
  • Initial irregular light spotting
dbp:rateType
  • Failure
dbp:reversibility
  • Provided correctly inserted
dbp:stdProtectionYesno
  • No
dbp:typicalFailure%_
  • 0.050000 (xsd:double)
dbp:userReminders
  • 1.57788E8
dbp:weightGainLoss
  • No proven effect
dct:subject
http://purl.org/linguistics/gold/hypernym
rdf:type
rdfs:comment
  • Norplant es la antigua marca de un implante subcutáneo usado como método anticonceptivo desarrollado en 1983 en Finlandia. 'Jadelle (Norplant II) es el nombre de la marca del implante de segunda generación aprobado en 1996. (es)
  • Norplant é uma forma de contraceptivo composto por seis pequenas cápsulas de silicone que são implantadas sob a pele do braço, sendo eficientes durante cinco anos. O Norplant II (Jadelle) consiste de dois pequenos bastões de silicone que são também implantados no braço. Implante impede a ovulação e quando ele não consegue impedir-la e ocorre a fecundação, forma-se o zigoto, implante impede a sua nidação através de alterações causadas à espessura do endométrio. (pt)
  • Levonorgestrel implants, sold under the brandnames Norplant among others, is a type of contraceptive implant for birth control. It was developed by Sheldon J. Segal and Horatio B. Croxatto at the Population Council beginning in 1966, with the first clinical trial in Chile in 1974. It was first approved in Finland on November 23, 1983, where it was manufactured by Leiras Oy Pharmaceuticals. The original Norplant consisted of a set of six small (2.4 mm × 34 mm) silicone capsules, each filled with 36 mg of levonorgestrel (a progestin used in many birth control pills) implanted subdermally in the upper arm and effective for five years. The original (six capsule) Norplant's production has been phased out; USAID's contract ran until December 2006.The original (six capsule) Norplant was approved (en)
rdfs:label
  • Levonorgestrel implant (en)
  • Norplant (es)
  • Norplant (pt)
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