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- Hexachlorophen ist ein chloriertes Diphenol und damit ein Chlorkohlenwasserstoff, der als Desinfektionsmittel Verwendung findet.
- El hexaclorofeno es una sustancia bactericida y fungicida tóxica. Usado antiguamente para el tratamiento tópico de la piel. Sus efectos neurotóxicos se observaron en los años 70, cuando se bañaba a los recién nacidos para evitar infecciones. Se absorbe por la piel y produce edema intramielínico seguido de desmialinización (sobre todo en intoxicaciones severas). La hinchazón del cerebro produce un aumento de la presión intracraneal y también afecta a los fotoreceptores de la retina. Los síntomas son debilidad generalizada, confusión, convulsiones, y en intoxicaciones severas, coma y muerte.
- L'esaclorofene è una sostanza disinfettante e battericida, utilizzato per formulazioni ad uso esterno e per la disinfezione della mucosa orale come saponi e dentifrici. Si presenta sottoforma di polvere di colore bianco, quasi inodore o con un lieve odore di fenolo. Assorbito per via cutanea, ad alte concentrazioni può risultare letale.
- Hexachlorofeen is een organische verbinding met als brutoformule C13H6Cl6O2. Het is een reukloos en wit kristallijn poeder.
- Hexaclorofeno é um antisséptico, derivado halogenado do fenol que possui ação bacteriostática e detergente. É usado em sabões, óleos de banho e detergentes.
- Hexachlorophene, also known as Nabac, is a disinfectant. The compound occurs as a white to light-tan crystalline powder, which either is odorless or produces a slightly phenolic odor. In medicine, hexachlorophene is very useful as a topical anti-infective, anti-bacterial agent, often used in soaps and toothpaste. It is also used in agriculture as a soil fungicide, plant bactericide, and acaricide. Hexachlorophene products can be lethal from percutaneous (through the skin) absorption. Children may be specifically susceptible. Hexachlorophene (6.3%) was added to “baby powder” in France due to a manufacturing error. It, or possibly contaminating dioxins, caused encephalopathy and ulcerative skin lesions. 36 of 204 exposed children died within a few days of exposure. Two companies manufactured over-the-counter preparations. One, by The Mennen Company, Morristown, NJ, was known as Baby Magic Bath. However, Mennen recalled the product, and all bottles were taken off retail shelves. Right after the withdrawal, there was an outbreak of Staphylococcus infections in hospitals across the USA. A commercial preparation of the drug, pHisoHex, was widely used as a very effective antibacterial skin cleanser in the treatment of acne. In the U.S. during the 1960s, it was available over the counter, and remains available as a prescription body wash. In the E.U. during the 1970s and 1980s, it was available over the counter. A related product, pHisoAc, was used as a skin mask to dry and peel away acne lesions. Another preparation, pHiso-Scrub, was a hexachlorophene-impregnated sponge for scrubbing; it has since been discontinued. In 1969, hexachlorophene became suspected of causing cancer, and studies determined that oral ingestion of hexachlorophene led to weakness and paralysis in laboratory rats. In 1973, after studies found relatively high concentrations of hexachlorophene in the blood of neonates washed with a 3% solution it was withdrawn from over-the-counter sales, though still available by prescription . A 1978 study undertaken by the U.S. National Institutes of Health, indicated that hexachlorophene does not cause cancer. However, the MSDS still lists this compound as an experimental teratogen. Possibly because of the previous questions concerning its effects, most dermatologists today do not prescribe it for acne treatment. Several substitute products were developed, but none had the germ-killing capability of hexachlorophene.
- L'hexachlorophène est un puissant bactéricide créé par la société Givaudan. Son utilisation dans le talc pour bébés fut longtemps considérée comme bénigne jusqu'à l'éclatement de l'affaire du talc Morhange. L'étude de la toxicité de ce produit a été réduite à sa plus simple expression, et se semble pas avoir jamais été totalement publiée . Le laboratoire aurait simplement fait consommer ce produit (en le mélangeant à l'alimentation) à une dizaine de cochons-d'Inde morts dans les trois jours. Ces résultats inquiétants sont restés confidentiels, les laboratoires étant pressés par le temps, en 1939. À l'époque, rien n'impose de contrôle sur les cosmétiques. L'hexachlorophène avait le double avantage (pour ses producteurs) de faire vendre un produit cosmétique plus cher en le faisant passer pour un médicament. L'hexachlorophène a été très longtemps commercialisé aux industries sous le nom de « G11 », le cachant ainsi des scientifiques.
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- Hexachlorophen ist ein chloriertes Diphenol und damit ein Chlorkohlenwasserstoff, der als Desinfektionsmittel Verwendung findet.
- L'esaclorofene è una sostanza disinfettante e battericida, utilizzato per formulazioni ad uso esterno e per la disinfezione della mucosa orale come saponi e dentifrici. Si presenta sottoforma di polvere di colore bianco, quasi inodore o con un lieve odore di fenolo. Assorbito per via cutanea, ad alte concentrazioni può risultare letale.
- Hexachlorofeen is een organische verbinding met als brutoformule C13H6Cl6O2. Het is een reukloos en wit kristallijn poeder.
- Hexaclorofeno é um antisséptico, derivado halogenado do fenol que possui ação bacteriostática e detergente. É usado em sabões, óleos de banho e detergentes.
- El hexaclorofeno es una sustancia bactericida y fungicida tóxica. Usado antiguamente para el tratamiento tópico de la piel. Sus efectos neurotóxicos se observaron en los años 70, cuando se bañaba a los recién nacidos para evitar infecciones. Se absorbe por la piel y produce edema intramielínico seguido de desmialinización (sobre todo en intoxicaciones severas). La hinchazón del cerebro produce un aumento de la presión intracraneal y también afecta a los fotoreceptores de la retina.
- Hexachlorophene, also known as Nabac, is a disinfectant. The compound occurs as a white to light-tan crystalline powder, which either is odorless or produces a slightly phenolic odor. In medicine, hexachlorophene is very useful as a topical anti-infective, anti-bacterial agent, often used in soaps and toothpaste. It is also used in agriculture as a soil fungicide, plant bactericide, and acaricide. Hexachlorophene products can be lethal from percutaneous (through the skin) absorption.
- L'hexachlorophène est un puissant bactéricide créé par la société Givaudan. Son utilisation dans le talc pour bébés fut longtemps considérée comme bénigne jusqu'à l'éclatement de l'affaire du talc Morhange. L'étude de la toxicité de ce produit a été réduite à sa plus simple expression, et se semble pas avoir jamais été totalement publiée . Le laboratoire aurait simplement fait consommer ce produit (en le mélangeant à l'alimentation) à une dizaine de cochons-d'Inde morts dans les trois jours.
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