hERG (the human Ether-à-go-go Related Gene) is a gene that codes for a protein known as Kv11.1 potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart that coordinates the heart's beating (i.e. , the hERG channel mediates the repolarizing IKr current in the cardiac action potential).
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- Der HERG-Kanal (Abk. für engl. Human Ether-a-go-go Related Gene) ist ein spannungsaktivierter, einwärtsgleichrichtender Kaliumkanal in Herzmuskelzellen. Der Kanal besteht aus vier Untereinheiten mit je sechs Transmembrandomänen und ist für die teilweise Repolarisation durch einen schnellen Kaliumausstrom IKr während des Aktionspotentials im Herzen verantwortlich.
- hERG (the human Ether-à-go-go Related Gene) is a gene that codes for a protein known as Kv11.1 potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart that coordinates the heart's beating (i.e. , the hERG channel mediates the repolarizing IKr current in the cardiac action potential). When this channel's ability to conduct electrical current across the cell membrane is inhibited or compromised, either by application of drugs or by rare mutations in some families, it can result in a potentially fatal disorder called long QT syndrome; a number of clinically successful drugs in the market have had the tendency to inhibit hERG, and create a concomitant risk of sudden death, as an unwanted side effect, which has made hERG inhibition an important antitarget which must be avoided during drug development. hERG has also been associated with modulating the functions of some cells of the nervous system and with establishing and maintaining cancer-like features in leukemic cells.
- hERG (human Ether-a-go-go Related Gene) とは、心筋活動電位の再分極を担う、 カリウムイオンチャンネルKv11.1をコードする遺伝子である。
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- Der HERG-Kanal (Abk. für engl. Human Ether-a-go-go Related Gene) ist ein spannungsaktivierter, einwärtsgleichrichtender Kaliumkanal in Herzmuskelzellen. Der Kanal besteht aus vier Untereinheiten mit je sechs Transmembrandomänen und ist für die teilweise Repolarisation durch einen schnellen Kaliumausstrom IKr während des Aktionspotentials im Herzen verantwortlich.
- hERG (human Ether-a-go-go Related Gene) とは、心筋活動電位の再分極を担う、 カリウムイオンチャンネルKv11.1をコードする遺伝子である。
- hERG (the human Ether-à-go-go Related Gene) is a gene that codes for a protein known as Kv11.1 potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart that coordinates the heart's beating (i.e. , the hERG channel mediates the repolarizing IKr current in the cardiac action potential).
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