Gluten sensitivity (GS) encompasses a collection of medical conditions in which gluten has an adverse effect. For individuals with gluten-sensitive enteropathy, removal of gluten generally results in the restoration of villus architecture or lower lymphocyte densities in the intestine. With some sensitivities, improvements may be seen in the neurological state, but a clinical finding may not be clear.

PropertyValue
dbpprop:abstract
  • Gluten sensitivity (GS) encompasses a collection of medical conditions in which gluten has an adverse effect. For individuals with gluten-sensitive enteropathy, removal of gluten generally results in the restoration of villus architecture or lower lymphocyte densities in the intestine. With some sensitivities, improvements may be seen in the neurological state, but a clinical finding may not be clear. GS also can affect blood chemistry, treatability of certain autoimmune diseases, and/or an untreated improvement in autoimmune conditions. Gluten is composed of the sticky, storage proteins found in wheat. Gluten-sensitive enteropathy (GSE) can range from mild inflammation of the mucosa of the small intestine to severe coeliac disease. The term gluten-sensitive is applicable when a probable diagnosis of GSE based on conditions such as dermatitis herpetiformis. However, GS may be used in ambiguous situations when other conditions may be possible. For example, wheat allergies to gluten can result in anaphylaxis while others may be difficult to diagnose because of some of the cryptic inflammatory properties of wheat proteins. The term 'gluten sensitivity' is typically applied when diagnostic testing is not done because of prolonged gluten-free diet and/or refusal of gluten-challenge prior to biopsy. The gluten-sensitive designation may not be appropriate in all cases, as wheat allergies are often directed toward albumins or globulins of wheat, or the person may have a sensitivity to proteins commonly found with wheat products. Therefore diagnostic criteria are preferred. The relationship between gluten and these various sensitivities is complex. For gluten enteropathy, T-cell reactivity is almost entirely restricted to prolamin-glutelin/species within the grass tribe Triticeae, and especially α-gliadins of wheat. For a tiny minority of GSE, inflammatory responses may extend to cover oats. Gluten allergies may extend over wide taxa or may be specific to certain wheat proteins and allergies may include oats. Gluten sensitivity should have a defined cause, although not apparent always with first examination, affected individuals should eventually fall into GSE or wheat allergy. Only rarely should gluten sensitivity be idiopathic. Idiopathic gluten sensitivity (IGS) arises "spontaneously or from an obscure or unknown cause" and may involve neuropathy, myopathy, dermal, or intestinal abnormalities. Anti-gliadin antibodies are the primary link between gluten and idiopathic sensitivity in instances in which enteropathy or allergy are not clearly involved. This form of gluten sensitivity is controversial at the moment.
dbpprop:hasPhotoCollection
dbpprop:reference
rdf:type
rdfs:comment
  • Gluten sensitivity (GS) encompasses a collection of medical conditions in which gluten has an adverse effect. For individuals with gluten-sensitive enteropathy, removal of gluten generally results in the restoration of villus architecture or lower lymphocyte densities in the intestine. With some sensitivities, improvements may be seen in the neurological state, but a clinical finding may not be clear.
rdfs:label
  • Gluten sensitivity
owl:sameAs
skos:subject
foaf:page
is dbpprop:redirect of
is owl:sameAs of