About: G protein-coupled inwardly-rectifying potassium channel

The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of inward-rectifier potassium ion channels which are activated (opened) via a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs). GPCRs in turn release activated G-protein βγ- subunits (Gβγ) from inactive heterotrimeric G protein complexes (Gαβγ). Finally, the Gβγ dimeric protein interacts with GIRK channels to open them so that they become permeable to potassium ions, resulting in hyperpolarization of the cell membrane. G protein-coupled inwardly-rectifying potassium channels are a type of G protein-gated ion channels because of this direct activation of GIRK channels by G protein subunits.

Property	Value
dbo:abstract	Le courant potassique rectifiant activé par les protéines G ou GIRK, pour l'anglais G-protein activated Inwardly Rectifying K+ current, appartient à la famille des courants potassiques rectifiant. Le terme rectifiant est ici utilisé en référence au composé électronique, le rectifieur, qui n'est conducteur que pour une polarité. La séparation du complexe trimèrique des protéines G active ce courant via les sous-unités "beta" et "gamma". Ce courant entraîne une hyperpolarisation du potentiel de repos qui inhibe le neurone. (fr) The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of inward-rectifier potassium ion channels which are activated (opened) via a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs). GPCRs in turn release activated G-protein βγ- subunits (Gβγ) from inactive heterotrimeric G protein complexes (Gαβγ). Finally, the Gβγ dimeric protein interacts with GIRK channels to open them so that they become permeable to potassium ions, resulting in hyperpolarization of the cell membrane. G protein-coupled inwardly-rectifying potassium channels are a type of G protein-gated ion channels because of this direct activation of GIRK channels by G protein subunits. GIRK1 to GIRK3 are distributed broadly in the central nervous system, where their distributions overlap. GIRK4, instead, is found primarily in the heart. (en) G-белок-связанные калиевые каналы внутреннего выпрямления (так называемые GIRK) — это подсемейство калиевых каналов внутреннего выпрямления, которые активируются (открываются) вследствие передачи сигнала с активированного вследствие связывания лиганда-агониста G-белок-связанного рецептора, вследствие чего от G-белка отсоединяется димер из βγ-субъединиц, который и активирует GIRK. Каналы подтипа GIRK1, GIRK2 и GIRK3 широко представлены в ЦНС, где их области распределения частично перекрываются. Каналы подтипа GIRK4, однако, в основном находятся в сердце. (ru)
dbo:arm	q
dbo:band	24 22.1 24.1 23.2
dbo:chromosome	2 1 11 21
dbo:entrezgene	3762 3763 3765 3760
dbo:hgncid	6264 6270 6266 6267
dbo:omim	600734 (xsd:integer) 600877 (xsd:integer) 600932 (xsd:integer) 601534 (xsd:integer)
dbo:refseq	NM_000890 NM_002239 NM_002240 NM_004983
dbo:symbol	KCNJ3 KCNJ5 KCNJ6 KCNJ7, Kir3.2, GIRK2, KATP2, BIR1, hiGIRK2 KCNJ9 Kir3.1, GIRK1, KGA Kir3.3, GIRK3 Kir3.4, CIR, KATP1, GIRK4
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dbp:iupharId	yes
dct:subject	dbc:Ion_channels
http://purl.org/linguistics/gold/hypernym	dbr:Family
rdf:type	owl:Thing wikidata:Q206229 wikidata:Q8054 dbo:Biomolecule dbo:Protein umbel-rc:ProteinMolecule yago:WikicatIonChannels yago:Abstraction100002137 yago:Act100030358 yago:Channel106259898 yago:Communication106252138 yago:Event100029378 yago:PsychologicalFeature100023100 yago:Transmission106251781 yago:YagoPermanentlyLocatedEntity
rdfs:comment	Le courant potassique rectifiant activé par les protéines G ou GIRK, pour l'anglais G-protein activated Inwardly Rectifying K+ current, appartient à la famille des courants potassiques rectifiant. Le terme rectifiant est ici utilisé en référence au composé électronique, le rectifieur, qui n'est conducteur que pour une polarité. La séparation du complexe trimèrique des protéines G active ce courant via les sous-unités "beta" et "gamma". Ce courant entraîne une hyperpolarisation du potentiel de repos qui inhibe le neurone. (fr) G-белок-связанные калиевые каналы внутреннего выпрямления (так называемые GIRK) — это подсемейство калиевых каналов внутреннего выпрямления, которые активируются (открываются) вследствие передачи сигнала с активированного вследствие связывания лиганда-агониста G-белок-связанного рецептора, вследствие чего от G-белка отсоединяется димер из βγ-субъединиц, который и активирует GIRK. Каналы подтипа GIRK1, GIRK2 и GIRK3 широко представлены в ЦНС, где их области распределения частично перекрываются. Каналы подтипа GIRK4, однако, в основном находятся в сердце. (ru) The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of inward-rectifier potassium ion channels which are activated (opened) via a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs). GPCRs in turn release activated G-protein βγ- subunits (Gβγ) from inactive heterotrimeric G protein complexes (Gαβγ). Finally, the Gβγ dimeric protein interacts with GIRK channels to open them so that they become permeable to potassium ions, resulting in hyperpolarization of the cell membrane. G protein-coupled inwardly-rectifying potassium channels are a type of G protein-gated ion channels because of this direct activation of GIRK channels by G protein subunits. (en)
rdfs:label	Courant potassique rectifiant activé par les protéines G (fr) G protein-coupled inwardly-rectifying potassium channel (en) GIRK (ru)
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foaf:name	potassium inwardly-rectifying channel, subfamily J, member 9 (en) potassium inwardly-rectifying channel, subfamily J, member 6 (en) potassium inwardly-rectifying channel, subfamily J, member 3 (en) potassium inwardly-rectifying channel, subfamily J, member 5 (en)
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