The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of inward-rectifier potassium ion channels which are activated (opened) via a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs). GPCRs in turn release activated G-protein βγ- subunits from inactive heterotrimeric G protein complexes (Gαβγ).

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dbpedia-owl:abstract
  • The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of inward-rectifier potassium ion channels which are activated (opened) via a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs). GPCRs in turn release activated G-protein βγ- subunits from inactive heterotrimeric G protein complexes (Gαβγ). Finally, the Gβγ dimeric protein interacts with GIRK channels to open them so that they become permeable to potassium ions, resulting in hyperpolarization of the cell. G protein-coupled inwardly-rectifying potassium channels are a type of G protein-gated ion channels because of this direct activation of GIRK channels by G protein subunits. GIRK1 to GIRK3 are distributed broadly in the central nervous system, where their distributions overlap. GIRK4, instead, is found primarily in the heart.
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dbpedia-owl:symbol
  • KCNJ3
  • KCNJ5
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  • KCNJ9
  • KCNJ7, Kir3.2, GIRK2, KATP2, BIR1, hiGIRK2
  • Kir3.1, GIRK1, KGA
  • Kir3.3, GIRK3
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  • KCNJ7, Kir3.2, GIRK2, KATP2, BIR1, hiGIRK2
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  • Kir3.3, GIRK3
  • Kir3.4, CIR, KATP1, GIRK4
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dcterms:subject
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rdfs:comment
  • The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of inward-rectifier potassium ion channels which are activated (opened) via a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs). GPCRs in turn release activated G-protein βγ- subunits from inactive heterotrimeric G protein complexes (Gαβγ).
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  • G protein-coupled inwardly-rectifying potassium channel
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  • potassium inwardly-rectifying channel, subfamily J, member 9
  • potassium inwardly-rectifying channel, subfamily J, member 6
  • potassium inwardly-rectifying channel, subfamily J, member 3
  • potassium inwardly-rectifying channel, subfamily J, member 5
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