Flutoprazepam (Restas) is a drug which is a benzodiazepine. It was patented in Japan by Sumitomo in 1972 and its medical use remains mostly confined to that country. Its muscle relaxant properties are approximately equivalent to those of diazepam - however, it has more powerful sedative, hypnotic, anxiolytic and anticonvulsant effects and is around four times more potent by weight compared to diazepam. It is longer acting than diazepam due to its long-acting active metabolites, which contribute significantly to its effects.

Property Value
dbo:abstract
  • フルトプラゼパム (Flutoprazepam)とは、ベンゾジアゼピン系の抗不安薬の一種である。作用の強さや、長時間の作用継続性から、持続性心身安定剤とされている。日本では商品名レスタスでMSDより発売されている。最高血中濃度到達時間は4~8時間、半減期は190時間程度である。 (ja)
  • Flutoprazepam (Restas) is a drug which is a benzodiazepine. It was patented in Japan by Sumitomo in 1972 and its medical use remains mostly confined to that country. Its muscle relaxant properties are approximately equivalent to those of diazepam - however, it has more powerful sedative, hypnotic, anxiolytic and anticonvulsant effects and is around four times more potent by weight compared to diazepam. It is longer acting than diazepam due to its long-acting active metabolites, which contribute significantly to its effects. Flutoprazepam is typically used for the treatment of severe insomnia and may also be used for treating stomach ulcers. Flutoprazepam is currently a Schedule IV drug under the international Convention on Psychotropic Substances of 1971. * In Singapore, flutoprazepam is a Class C-Schedule II drug under the Misuse of Drugs Act. * In Thailand, flutoprazepam is a Schedule III psychotropic substance. * In Hong Kong, flutoprazepam is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. Flutoprazepam can only be used legally by health professionals and for university research purposes. The substance can be given by pharmacists under a prescription. Anyone who supplies the substance without prescription can be fined $10000 (HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 (HKD) fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 (HKD) fine and/or 7 years of jail time. (en)
dbo:atcPrefix
  • none
dbo:bioavailability
  • 80.000000 (xsd:float)
dbo:casNumber
  • 25967-29-7
dbo:fdaUniiCode
  • 2GHY1101MM
dbo:iupacName
  • 7-chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one (en)
dbo:pubchem
  • 3400
dbo:thumbnail
dbo:wikiPageID
  • 13398239 (xsd:integer)
dbo:wikiPageRevisionID
  • 736043343 (xsd:integer)
dbp:c
  • 19 (xsd:integer)
dbp:chembl
  • 2106743 (xsd:integer)
dbp:chemspiderid
  • 3283 (xsd:integer)
dbp:cl
  • 1 (xsd:integer)
dbp:eliminationHalfLife
  • -324000.0
dbp:excretion
  • Renal
dbp:f
  • 1 (xsd:integer)
dbp:h
  • 16 (xsd:integer)
dbp:image
  • Flutoprazepam ball-and-stick.png
dbp:kegg
  • D01279
dbp:legalCa
  • Schedule IV
dbp:metabolism
  • Hepatic
dbp:molecularWeight
  • 342.795000 (xsd:double)
dbp:n
  • 2 (xsd:integer)
dbp:o
  • 1 (xsd:integer)
dbp:pregnancyUs
  • X
dbp:routesOfAdministration
  • Oral, Intravenous
dbp:smiles
  • FC1=CC=CC=C1C2=NCC=O
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • OFVXPDXXVSGEPX-UHFFFAOYSA-N
dbp:tradename
  • Restas
dbp:verifiedrevid
  • 447931828 (xsd:integer)
dbp:watchedfields
  • changed
dbp:width
  • 175 (xsd:integer)
  • 180 (xsd:integer)
dct:subject
http://purl.org/linguistics/gold/hypernym
rdf:type
rdfs:comment
  • フルトプラゼパム (Flutoprazepam)とは、ベンゾジアゼピン系の抗不安薬の一種である。作用の強さや、長時間の作用継続性から、持続性心身安定剤とされている。日本では商品名レスタスでMSDより発売されている。最高血中濃度到達時間は4~8時間、半減期は190時間程度である。 (ja)
  • Flutoprazepam (Restas) is a drug which is a benzodiazepine. It was patented in Japan by Sumitomo in 1972 and its medical use remains mostly confined to that country. Its muscle relaxant properties are approximately equivalent to those of diazepam - however, it has more powerful sedative, hypnotic, anxiolytic and anticonvulsant effects and is around four times more potent by weight compared to diazepam. It is longer acting than diazepam due to its long-acting active metabolites, which contribute significantly to its effects. (en)
rdfs:label
  • フルトプラゼパム (ja)
  • Flutoprazepam (en)
owl:sameAs
prov:wasDerivedFrom
foaf:depiction
foaf:isPrimaryTopicOf
is foaf:primaryTopic of