Drug-induced lupus erythematosus (DIL or DILE) is an autoimmune disorder, similar to systemic lupus erythematosus (SLE), which is induced by chronic use of certain drugs. These drugs cause an autoimmune response (the body attacks its own cells) producing symptoms similar to those of SLE. There are 38 known medications to cause DIL but there are three that report the highest number of cases: hydralazine, procainamide, and isoniazid.

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  • Drug-induced lupus erythematosus (DIL or DILE) is an autoimmune disorder, similar to systemic lupus erythematosus (SLE), which is induced by chronic use of certain drugs. These drugs cause an autoimmune response (the body attacks its own cells) producing symptoms similar to those of SLE. There are 38 known medications to cause DIL but there are three that report the highest number of cases: hydralazine, procainamide, and isoniazid. While the criteria for diagnosing DIL has not been thoroughly established, symptoms of DIL include fever, elevated blood pressure, skin lesions, and arthritis. Generally, the symptoms recede after discontinuing use of the drugs, but there are reported cases of DIL that do not go away completely after the offending drug is removed. While this may not be a prevailing illness in this age of heritable and non-transmittable diseases, research on drug-induced lupus could lead to a greater understanding on the immune system. This greater understanding of our immune systems could lead to breakthroughs in many other diseases such as HIV, influenza, and other communicable diseases. Research on this topic also has pharmaceutical implications as to avoid immune reactions from future drugs.
  • Toczeń polekowy – zespół objawów klinicznych podobnych do objawów występujących w przebiegu tocznia układowego trzewnego, których wystąpienie zostało uwarunkowane przez stosownie niektórych leków. Cechą charakterystyczną tocznia polekowego jest pojawienie się przeciwciał przeciwko histonom (ponad 95% przypadków) i rzadziej przeciw ssDNA, brak zaburzeń hematologicznych, nerkowych oraz stopniowa poprawa po odstawieniu leku wywołującego objawy.
  • O lúpus eritematoso induzido por drogas ocorre como conseqüência do uso de certas drogas ou medicamentos. Os sintomas são muito parecidos com o lúpus eritematoso sistêmico. Inclusive os próprios medicamentos para tratar o lúpus, podem levar a um estado de lúpus induzido. Por isso é preciso ter certeza absoluta do diagnóstico antes de tomar remédios perigosos como; cortisona, antimaláricos como reuquinol, antiinflamatórios em geral. Algumas drogas já foram detectadas como facilitadoras do desenvolvimento de lúpus. É o caso, por exemplo, da hidralazina, medicamento para tratamento da hipertensão, ou da procainamida, usada para tratamento de algumas arritmias cardíacas. Entretanto, quando ocorre a doença auto-imune devido ao uso dessas substâncias, isso depende mais da pessoa que da própria substância, ou seja, não são todas as pessoas que tomam esses produtos que desenvolverão o lúpus, mas apenas uma pequena porcentagem delas. Isso significa que a imunidade dessas pessoas vulneráveis à doença auto-imune é que é o problema, propriamente dito.
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  • Drug-induced lupus erythematosus (DIL or DILE) is an autoimmune disorder, similar to systemic lupus erythematosus (SLE), which is induced by chronic use of certain drugs. These drugs cause an autoimmune response (the body attacks its own cells) producing symptoms similar to those of SLE. There are 38 known medications to cause DIL but there are three that report the highest number of cases: hydralazine, procainamide, and isoniazid.
  • Toczeń polekowy – zespół objawów klinicznych podobnych do objawów występujących w przebiegu tocznia układowego trzewnego, których wystąpienie zostało uwarunkowane przez stosownie niektórych leków. Cechą charakterystyczną tocznia polekowego jest pojawienie się przeciwciał przeciwko histonom (ponad 95% przypadków) i rzadziej przeciw ssDNA, brak zaburzeń hematologicznych, nerkowych oraz stopniowa poprawa po odstawieniu leku wywołującego objawy.
  • O lúpus eritematoso induzido por drogas ocorre como conseqüência do uso de certas drogas ou medicamentos. Os sintomas são muito parecidos com o lúpus eritematoso sistêmico. Inclusive os próprios medicamentos para tratar o lúpus, podem levar a um estado de lúpus induzido. Por isso é preciso ter certeza absoluta do diagnóstico antes de tomar remédios perigosos como; cortisona, antimaláricos como reuquinol, antiinflamatórios em geral.
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  • Lúpus eritematoso induzido por drogas
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