D(3) dopamine receptor is a protein that in humans is encoded by the DRD3 gene. This gene encodes the D3 subtype of the dopamine receptor. The D3 subtype inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson's disease.

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dbpedia-owl:abstract
  • D(3) dopamine receptor is a protein that in humans is encoded by the DRD3 gene. This gene encodes the D3 subtype of the dopamine receptor. The D3 subtype inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson's disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). D3 agonists like 7-OH-DPAT, pramipexole, and rotigotine, among others, display antidepressant effects in rodent models of depression.
  • 0 receptor D3 de dopamina, também conhecido como DRD3, é um gene humano. Este gene codifica o subtipo D3 de receptor de dopamina. O subtipo D3 inibe a adenilato ciclase, através de proteínas G inibitórias. Este receptor é expresso em regiões mais antigas filogeneticamente do cérebro, sugerindo que este receptor desempenha um papel importante nas funções cognitivas e emocionais. É um alvo para dogas que tratam a esquizofrenia, adicção de drogas e doença de Parquinson. O spicing alternativo deste gene resulta em múltiplas variantes de transcriptos que codificam diferentes isoformas..
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  • 1814
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  • D(3) dopamine receptor is a protein that in humans is encoded by the DRD3 gene. This gene encodes the D3 subtype of the dopamine receptor. The D3 subtype inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson's disease.
  • 0 receptor D3 de dopamina, também conhecido como DRD3, é um gene humano. Este gene codifica o subtipo D3 de receptor de dopamina. O subtipo D3 inibe a adenilato ciclase, através de proteínas G inibitórias. Este receptor é expresso em regiões mais antigas filogeneticamente do cérebro, sugerindo que este receptor desempenha um papel importante nas funções cognitivas e emocionais. É um alvo para dogas que tratam a esquizofrenia, adicção de drogas e doença de Parquinson.
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  • Receptor D3 de dopamina
  • Dopamine receptor D3
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