Donitriptan (INN) (code name F-11356) is a triptan drug which was investigated as an antimigraine agent but ultimately was never marketed. It acts as a high-affinity, high-efficacy/near-full agonist of the 5-HT1B (pKi = 9.4–10.1; IA = 94%) and 5-HT1D receptors (pKi = 9.3–10.2; IA = 97%), and is among the most potent of the triptan series of drugs. Donitriptan was being developed in France by bioMérieux-Pierre Fabre and made it to phase II clinical trials in Europe before development was discontinued.

Property Value
dbo:abstract
  • دونيتريبتان (بالإنجليزية: Donitriptan) هو دواء من مجموعة التريبتانات أجريت عليه دراسات بوصفه مضاد صداع نصفي لكنه لم يسوق أبدا. وهو من أشد أدوية التريبتانات فاعلية. أجريت الدراسات في فرنسا على دونيتريبتان بواسطة بيومريو ومختبرات بيير فابر واجريت المرحلة الثانية من التجارب السريرية في أوروبا قبل إيقافها. (ar)
  • Donitriptan (INN) (code name F-11356) is a triptan drug which was investigated as an antimigraine agent but ultimately was never marketed. It acts as a high-affinity, high-efficacy/near-full agonist of the 5-HT1B (pKi = 9.4–10.1; IA = 94%) and 5-HT1D receptors (pKi = 9.3–10.2; IA = 97%), and is among the most potent of the triptan series of drugs. Donitriptan was being developed in France by bioMérieux-Pierre Fabre and made it to phase II clinical trials in Europe before development was discontinued. (en)
dbo:atcPrefix
  • None
dbo:casNumber
  • 170912-52-4
dbo:iupacName
  • 4-[4-({[3-(2-Aminoethyl)-1H-indol-5-yl]oxy}acetyl)-1-piperazinyl]benzonitrile (en)
dbo:pubchem
  • 197706
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  • 1742428 (xsd:integer)
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  • 171128 (xsd:integer)
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  • 25 (xsd:integer)
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  • 403.477000 (xsd:double)
dbp:n
  • 5 (xsd:integer)
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  • 2 (xsd:integer)
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  • c1ccN2CCNCCOc3ccc4ccCCN
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  • 1 (xsd:integer)
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  • SOHCKWZVTCTQBG-UHFFFAOYSA-N
dct:subject
http://purl.org/linguistics/gold/hypernym
rdf:type
rdfs:comment
  • دونيتريبتان (بالإنجليزية: Donitriptan) هو دواء من مجموعة التريبتانات أجريت عليه دراسات بوصفه مضاد صداع نصفي لكنه لم يسوق أبدا. وهو من أشد أدوية التريبتانات فاعلية. أجريت الدراسات في فرنسا على دونيتريبتان بواسطة بيومريو ومختبرات بيير فابر واجريت المرحلة الثانية من التجارب السريرية في أوروبا قبل إيقافها. (ar)
  • Donitriptan (INN) (code name F-11356) is a triptan drug which was investigated as an antimigraine agent but ultimately was never marketed. It acts as a high-affinity, high-efficacy/near-full agonist of the 5-HT1B (pKi = 9.4–10.1; IA = 94%) and 5-HT1D receptors (pKi = 9.3–10.2; IA = 97%), and is among the most potent of the triptan series of drugs. Donitriptan was being developed in France by bioMérieux-Pierre Fabre and made it to phase II clinical trials in Europe before development was discontinued. (en)
rdfs:label
  • دونيتريبتان (ar)
  • Donitriptan (en)
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