Dolasetron (trade name Anzemet) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much antiemetic effect when symptoms are due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.

PropertyValue
dbpedia-owl:Drug/atcPrefix
  • A04
dbpedia-owl:Drug/atcSuffix
  • AA04
dbpedia-owl:Drug/casNumber
  • 115956-12-2
dbpedia-owl:Drug/drugbank
  • APRD00518
dbpedia-owl:Drug/iupacName
  • (3R)-10-oxo-8-azatricyclo[5.3.1.0]undec-5-yl 1H-indole-3-carboxylate
dbpedia-owl:Drug/pubchem
  • 60654
dbpedia-owl:atcPrefix
  • A04
dbpedia-owl:atcSuffix
  • AA04
dbpedia-owl:casNumber
  • 115956-12-2
dbpedia-owl:drugbank
  • APRD00518
dbpedia-owl:iupacName
  • (3R)-10-oxo-8-azatricyclo[5.3.1.0]undec-5-yl 1H-indole-3-carboxylate
dbpedia-owl:pubchem
  • 60654
dbpedia-owl:thumbnail
dbpprop:abstract
  • Dolasetron (trade name Anzemet) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much antiemetic effect when symptoms are due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors. Dolasetron breaks down slowly, staying in the body for a long time. One dose usually lasts 4 to 9 hours and is usually administered once or twice daily. This drug is removed from the body by the liver and kidneys.
dbpprop:atcPrefix
  • A04
dbpprop:atcSuffix
  • AA04
dbpprop:c
  • 19 (xsd:integer)
dbpprop:casNumber
  • 115956-12-2
dbpprop:drugbank
  • APRD00518
dbpprop:eliminationHalfLife
  • 8.1 hours
dbpprop:h
  • 20 (xsd:integer)
dbpprop:hasPhotoCollection
dbpprop:image
  • Dolasetron_3D.png
dbpprop:iupacName
  • 3R)-10-oxo-8-azatricyclo[5.3.1.03,8]undec-5-yl 1H-indole-3-carboxylate
dbpprop:legalStatus
  • Rx only
dbpprop:molecularWeight
  • 324.374 g/mol
dbpprop:n
  • 2 (xsd:integer)
dbpprop:o
  • 3 (xsd:integer)
dbpprop:pregnancyCategory
  • B (US)
dbpprop:proteinBound
  • 69 to 77%
dbpprop:pubchem
  • 60654 (xsd:integer)
dbpprop:routesOfAdministration
  • Intravenous, oral
dbpprop:wikiPageUsesTemplate
rdf:type
rdfs:comment
  • Dolasetron (trade name Anzemet) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much antiemetic effect when symptoms are due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors.
rdfs:label
  • Dolasetron
owl:sameAs
skos:subject
foaf:depiction
foaf:page
is dbpprop:redirect of
is owl:sameAs of